RT期刊文章SR电子T1协会灌注损伤变量与功能结果轻度中风患者和大血管阻塞管理医学摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e627 OP e638 10.1212 / WNL。首页100签证官0000000000201498是6 A1彭王A1 Wenhuo陈A1 Chushuang陈A1安德鲁Bivard A1耿于马克·w·帕森斯林A1哈哈A1 A1代表激励年2023 UL //www.ez-admanager.com/content/100/6/e627.abstract AB背景和目标的最佳管理轻度中风患者和大血管闭塞(LVO)仍不清首页楚。本研究旨在确定灌注成像差的预测功能结果在这样的病人。这个回顾性队列研究方法选择国际中风病人的灌注成像注册中心在2011年8月和2022年4月。注册表注册急性缺血性中风患者和基线CT灌注扫描发病24小时内的。本研究发现患者症状轻微,定义的NIH卒中量表评分≤5。患者LVO前循环。本研究进一步选择病人的医疗管理和排除患者接受血管内治疗。主要结果是贫穷的功能性结果定义为改良Rankin规模的3 - 6 3个月。灌注损伤是由延迟时间> CTP 3秒。 Regression analyses were used to identify clinical and imaging variables that predicted poor functional outcome.Results A total of 139 patients with mild stroke were included, of whom 27 (19%) had poor functional outcome. Patients with poor outcome, compared with those with good outcome, had much larger perfusion lesion volume (median 80 mL vs 41 mL, p < 0.001). Perfusion lesion was a significant predictor of poor outcome in either univariable regression (crude OR = 1.02, 95% CI = [1.01–1.03]) or multivariable regression model (adjusted OR = 1.01, 95% CI = [1.01–1.02]), adjusting for occlusion site, good collaterals, baseline stroke severity, age, IV thrombolysis (IVT), and onset to scan time. A perfusion lesion of 65 mL was the optimal cutpoint to identify poor functional outcome (sensitivity = 59%, specificity = 77%). Patients with perfusion lesion ≥65 mL, compared with patients with perfusion lesion <65 mL, showed a much higher rate of poor functional outcome (38% vs 11%, p < 0.001). Of the 139 patients in this study, 95 received IVT. Patients treated with or without IVT did not influence their outcomes (crude OR = 0.74, 95% CI = [0.31–1.78]).Discussion A perfusion lesion of ≥65 mL predicted poor functional outcome in mild stroke patients with LVO.ASPECTS=Alberta Stroke Program Early CT Score; CBF=cerebral blood flow; CTP=CT perfusion; DT=delay time; EVT=endovascular thrombectomy; INSPIRE=International Stroke Perfusion Imaging Registry; IVT=IV thrombolysis; LVO=large vessel occlusion; NCCT=noncontrast CT; NIHSS=NIH Stroke Scale; PH=parenchymal hemorrhage; sICH=symptomatic intracerebral hemorrhage