TY -的T1 Infratentorial脑损伤患者疑似死亡的神经学神经标准JF -乔-神经病学SP - e443 LP - - 10.1212 / WNL e453做。首页0000000000201449六世- 100 - 4 AU -乔尔•内维斯伯瑞犬盟Guillaume Plourde AU -罗伊Nitulescu AU - j·戈登•博伊德盟-弗朗索瓦•马丁载体非盟- Philippe Couillard AU -马克。r . Keezer AU -安德烈亚斯·h·克雷默AU -萨姆·d·Shemie盟基督教Stapf AU -迈克尔快滑步Y1 - 2023/01/24 UR - //www.ez-admanager.com/content/100/4/e443.abstract N2 -背景和目标有一个缺乏数据的频率和预后infratentorial脑损伤患者首页疑似死亡的神经系统标准(DNC),这可能有助于科学不确定性的作用孤立的脑干死亡DNC的决心。我们的目的是合成患病率、特点、和演化的infratentorial脑损伤,包括孤立脑干死亡,患者中DNC的嫌疑。方法我们进行了一项系统回顾通过搜索Medline、Embase,循证医学评论,CINAHL完成,和灰色文献从开始到3月26日,2021年。我们选择队列和横断面研究,病例报告和案例系列,包括病人DNC的嫌疑。选择两个独立研究人员进行研究,数据收集、评估和风险的偏见。我们的主要结果是各自的患病率infratentorial脑损伤和孤立脑干死亡,我们使用mixed-effects meta-analyzed与扩散先验贝叶斯分层模型。我们二次结果infratentorial脑损伤患者的特点和演化和孤立脑干死亡。21个研究结果满足选择条件,其中大多数是中度到高偏差的风险。患者怀疑DNC, infratentorial脑损伤的患病率从2%到16% (n = 3602,意味着流行率:6.3%,95%最高密度区间(2.4% - -14.2%),而孤立的脑干死亡的患病率从1%到4% (n = 3692,意味着流行率:1.5%,95%最高密度区间(0.5% - -3.9%))。共有38个孤立脑干死亡病例临床特征数据和/或进化了。都有infratentorial中风。 Twenty patients had EEG background activity in the α or θ frequencies, 19 had preserved cerebral blood flow, 2 had preserved supratentorial cerebral perfusion, 2 had cortical responses to visual evoked potentials, and 1 had cortical responses to somatosensory evoked potentials. At the latest follow-up, 28 had progressed to whole-brain death.Discussion Studies with moderate to high risk of bias suggest that infratentorial brain injury is relatively uncommon among patients suspected of DNC. Isolated brainstem death is rarer and seems to carry a high risk of progression to whole-brain death. These findings require further high-quality investigation.DNC=death by neurologic criteria ER -