TY - T1的锻炼对患者抑郁症状的影响帕金森病JF -神经学乔-神经病学SP - e377 LP - e387做- 10.1212 / WNL。首页0000000000201453六世- 100 - 4盟Ryul金盟- Tae李李盟Hanall李盟- Kyung Ko盟做Beomseok全非盟- Nyeonju Kang Y1 - 2023/01/24 UR - //www.ez-admanager.com/content/100/4/e377.abstract N2 -首页背景和目的本研究的目的是提供明确的证据支持使用的运动来提高帕金森病(PD)患者的抑郁症状并调查是否这种效应不同运动类型和强度。方法三个独立评论员搜索随机对照试验(相关的),应用运动干预与抑郁症状作为PD患者的测量结果在PubMed和网络科学到2月28日,2022年。随机进行荟萃分析,标准化意味着之间的差异(smd)运动和控制干预对抑郁症状的影响CIs计算为95%。结果共有19个相关的包括1302例PD患者资格荟萃分析,我们得到23比较包括研究的数据合成。体育锻炼干预显示显著影响减少PD患者的抑郁症状(SMD = 0.829;95%可信区间= 0.516 - -1.142;p & lt;0.001)。主持人分析运动类型揭示了重要的积极作用结合运动干预(SMD = 1.111;188金宝慱官网下载95%可信区间= 0.635 - -1.587;p & lt; 0.001), whereas aerobic training alone failed to show significant effects (SMD = 0.202; 95% CI = −0.045 to 0.449; p = 0.108). Both light-to-moderate intensity exercises (SMD = 0.971; 95% CI = 0.521–1.421; p < 0.001) and moderate-to-vigorous intensity exercises (SMD = 0.779; 95% CI = 0.407–1.152; p < 0.001) significantly improved depressive symptoms with a small difference between the exercise intensities.Discussion Our results suggest that physical exercise has significant antidepressant effects in patients with PD. These effects seemed to be more closely associated with exercise type than intensity. Different types of exercise interventions may result in greater benefit and require further investigation.BDNF=brain-derived neurotrophic factor; BDI=Beck Depression Inventory; GDS=Geriatric Depression Scale; HADS=Hospital Anxiety and Depression Scale; HAM-D17=17-item Hamilton Depression Rating Scale; PD=Parkinson disease; RCT=randomized controlled trial; SDS=Self-rating Depression Scale; SMD=standardized mean difference; UPDRS=Unified Parkinson Disease Rating Scale ER -