@article {Cortesee308作者={罗莎Cortese和弗兰普拉多卡拉斯科牛蛙和卡门Alessia比安奇和华莱士Brownlee Floriana De旧金山和伊莎贝尔·德·拉巴斯和弗朗西斯科·Grussu卢卡斯海德尔和阿奴雅各巴里斯Kanber和丽丝Magnollay和理查德·尼古拉斯和阿南德旅行,腻过Yiannakas和艾哈迈德·t·Toosy雅艾尔Hacohen和弗雷德里克Barkhof和Olga Ciccarelli}, title ={区分多发性硬化症与成像视AQP4-Neuromyelitis谱系障碍和MOG-Antibody疾病},体积={100}={3},页面= {e308——e323} = {2023}, doi = {10.1212 / WNL。出版商0000000000201465}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标复发缓和多发性硬化(名RRMS) aquaporin-4抗体{\ t首页extendash}积极neuromyelitis视谱系障碍(AQP4-NMOSD)和髓少突细胞糖蛋白抗体{\ textendash}相关疾病(MOGAD)可能有重叠的临床特征。有一个未满足的需要成像标记区分血清学检查时不可用或模糊。我们评估是否成像特点的典型区别对待女士名RRMS AQP4-NMOSD和MOGAD单独和组合。方法成人、nonacute名RRMS患者前瞻性APQ4-NMOSD, MOGAD和健康对照者招募全国神经病学与神经外科医院(英国伦敦)和沃尔顿中心(英国利物浦)在2014年和2019年之间。首页他们经历了传统和先进的大脑、绳和视神经磁共振成像和光学相干断层扫描(OCT)。结果共有91个连续的患者(31名RRMS 30 APQ4-NMOSD, 30 MOGAD)和34名健康对照组被招募。最准确的区分名RRMS从AQP4-NMOSD措施的比例与中央静脉病变迹象(CVS) (84 \ % vs 33 \ %、准确性特异性/敏感性:91/88/93 \ % \ p < 0.001),其次是皮质病变(中值:2(范围:1 {\ textendash} 14)和1 (0 {\ textendash} 1)精度/特异性/敏感性:84/90/77 \ %,p = 0.002)和白质病变(意思是:39.07 (25.8 {\ textpm})和9.5 ({\ textpm} 14),精度/特异性/敏感性:78/84/73 \ %,p = 0.001)。更高比例的CVS的结合,皮质病变、视神经磁化传递率达到最高的精度区分名RRMS AQP4-NMOSD(精度/特异性/敏感性:95/92/97 \ %,p < 0.001)。最准确的措施支持名RRMS超过MOGAD白质病变(39.07 [25.8 {\ textpm}] vs 1 [{\ textpm} 2.3],准确性特异性/敏感性:94/94/93 \ %,p = 0.006),其次是皮质病变(2 (1 {\ textendash} 14)和1 (0 {\ textendash} 1)精度/特异性/敏感性:84/97/71 \ %,p = 0.004),和视网膜神经纤维层(RNFL)厚度(意思是:87.54 (13.83 {\ textpm})和75.54 (20.33 {\ textpm}),精度/特异性/敏感性:80/79/81 \ %,p = 0.009)。高皮质病变数量加上RNFL厚度最好的区分名RRMS MOGAD(精度/特异性/敏感性:84/92/77 \ %,p < 0.001)。讨论皮质病变、CVS和视神经标记实现高精度的区分名RRMS APQ4-NMOSD MOGAD。 This information may be useful in clinical practice, especially outside the acute phase and when serologic testing is ambiguous or not promptly available.Classification of Evidence This study provides Class II evidence that selected conventional and advanced brain, cord, and optic nerve MRI and OCT markers distinguish adult patients with RRMS from AQP4-NMOSD and MOGAD.9-HPT=9-hole peg test; Ab=antibody; AQP4-NMOSD=aquaporin-4 antibody{\textendash}positive neuromyelitis optica spectrum disorder; AUC=area under the curve; CBA=cell-based assay; CSA=cross-sectional area; CVS=central vein sign; DTI=diffusion tensor imaging; EDSS=Expanded Disability Status Scale; GCIPL=ganglion cell{\textendash}inner plexiform layer; MOGAD=myelin oligodendrocyte glycoprotein antibody{\textendash}associated disease; MTR=magnetization transfer ratio; OCT=optical coherence tomography; RC=regression coefficient; RRMS=relapsing-remitting multiple sclerosis; SWI=susceptibility-weighted imaging; TWT=timed 25-foot walk test}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/3/e308}, eprint = {//www.ez-admanager.com/content/100/3/e308.full.pdf}, journal = {Neurology} }