TY -的T1 -淀粉样蛋白和τ宠物对变化的影响诊断和患者管理JF -神经学乔-神经病学SP - e264 LP - e274做- 10.1212 / WNL。首页0000000000201389六世盟- 100 - 3 - Sho Shimohama盟——手冢AU - Takahata圭佑盟Shogyoku包子盟Hajime Tabuchi AU - Morinobu塞其非盟- Yuki Momota盟Natsumi铃木盟彩花森本晃司AU - Yu Iwabuchi盟Masahito日本久保田公司AU -山本Yasuharu盟Yasunori佐非盟- Shikimoto良盟祺Funaki AU - Yu Mimura盟manuscript Nishimoto AU -建筑师良盟Masahiro Jinzaki盟金Nakahara AU -学者Mimura盟Daisuke Ito Y1 - 2023/01/17 UR - //www.ez-admanager.com/content/100/3/e264.abstract N2 -先前的研究背景和目标评估诊断淀粉样宠物在选定研究人群的影响。首页然而,这些研究没有评估的临床影响淀粉样蛋白的结合和τ的宠物。我们的目的是评估协会2宠物的组合变化的诊断、治疗和管理记忆诊所队列。方法所有的参与者进行了淀粉样蛋白[18 f] florbetaben宠物和τ宠物使用[18 f]π- 2620或[18 f] Florzolotau,这可能是有用的(广告)tauopathies non-Alzheimer的诊断疾病。老年痴呆症专家确定预处理和post-PET诊断,存在于一个临床综合征(认知正常[CN],轻度认知障碍(MCI)和痴呆)和可疑病因,置信水平。此外,老年痴呆症专家决定病人治疗的辅助调查和管理。结果在126注册参与者中,84.9%完成了研究过程和被包含在分析(CN [n = 40], MCI (n = 25),广告(n = 20)和non-AD痴呆[n = 22])。病原学的诊断改变了CN在25.0%,与痴呆MCI的68.0%,23.8%。预处理和post-PET之间整体管理的变化发生在5.0%的CN, MCI的52.0%,和38.1%的痴呆症。 Logistic regression analysis revealed that tau PET has stronger associations with change management than amyloid PET in all participants and dementia groups.Discussion The combination of amyloid and tau PETs was associated with changes in management and diagnosis of MCI and dementia, and the second-generation tau PET has a strong impact on the changes in diagnosis and management in memory clinics.Classification of Evidence This study provides Class I evidence that the combination of amyloid and tau PETs was associated with changes in management and diagnosis of MCI and dementia.4R=4-repeat; Aβ=β-amyloid; AD=Alzheimer disease; ANOVA=analysis of variance; CBD=corticobasal degeneration; CBS=corticobasal syndrome; CDR=Clinical Dementia Rating; CI=cognitively impaired participants; CN=cognitive normal; FBB=florbetaben; FDA=US Food and Drug Administration; FTLD=frontotemporal lobar degeneration; GDS=Geriatric Depression Scale; GMP=good manufacturing practices; IDEAS=Imaging Dementia-Evidence for Amyloid Scanning; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; PSP=progressive supranuclear palsy; SUVR=standardized uptake value ratios; TBI=traumatic brain injury ER -