RT期刊文章SR电子T1淀粉样蛋白和τ宠物对变化的影响诊断和患者管理摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e264 OP e274 10.1212 / WNL。首页100签证官0000000000201389是3 A1商店Shimohama A1——手冢A1圭佑Takahata A1 Shogyoku包子A1 Hajime Tabuchi A1 Morinobu塞其A1徐怀钰Momota A1 Natsumi铃木A1彩花森本晃司A1 Yu Iwabuchi A1 Masahito日本久保田公司A1 Yasuharu山本A1 Yasunori佐A1坂Shikimoto A1祺Funaki A1 Yu Mimura A1 manuscript Nishimoto A1坂建筑师A1 Masahiro Jinzaki A1金Nakahara A1学者Mimura A1 Daisuke Ito年2023 UL //www.ez-admanager.com/content/100/3/e264.abstract AB先前的研究背景和目标评估诊断淀粉样宠物在选定研究人群的影响。首页然而,这些研究没有评估的临床影响淀粉样蛋白的结合和τ的宠物。我们的目的是评估协会2宠物的组合变化的诊断、治疗和管理记忆诊所队列。方法所有的参与者进行了淀粉样蛋白[18 f] florbetaben宠物和τ宠物使用[18 f]π- 2620或[18 f] Florzolotau,这可能是有用的(广告)tauopathies non-Alzheimer的诊断疾病。老年痴呆症专家确定预处理和post-PET诊断,存在于一个临床综合征(认知正常[CN],轻度认知障碍(MCI)和痴呆)和可疑病因,置信水平。此外,老年痴呆症专家决定病人治疗的辅助调查和管理。结果在126注册参与者中,84.9%完成了研究过程和被包含在分析(CN [n = 40], MCI (n = 25),广告(n = 20)和non-AD痴呆[n = 22])。病原学的诊断改变了CN在25.0%,与痴呆MCI的68.0%,23.8%。预处理和post-PET之间整体管理的变化发生在5.0%的CN, MCI的52.0%,和38.1%的痴呆症。 Logistic regression analysis revealed that tau PET has stronger associations with change management than amyloid PET in all participants and dementia groups.Discussion The combination of amyloid and tau PETs was associated with changes in management and diagnosis of MCI and dementia, and the second-generation tau PET has a strong impact on the changes in diagnosis and management in memory clinics.Classification of Evidence This study provides Class I evidence that the combination of amyloid and tau PETs was associated with changes in management and diagnosis of MCI and dementia.4R=4-repeat; Aβ=β-amyloid; AD=Alzheimer disease; ANOVA=analysis of variance; CBD=corticobasal degeneration; CBS=corticobasal syndrome; CDR=Clinical Dementia Rating; CI=cognitively impaired participants; CN=cognitive normal; FBB=florbetaben; FDA=US Food and Drug Administration; FTLD=frontotemporal lobar degeneration; GDS=Geriatric Depression Scale; GMP=good manufacturing practices; IDEAS=Imaging Dementia-Evidence for Amyloid Scanning; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; PSP=progressive supranuclear palsy; SUVR=standardized uptake value ratios; TBI=traumatic brain injury