RT杂志文章SR电子T1酒精摄入是急性中风的危险因素JF神经学JO神经学FD Lippincott Williams & Wilkins SP e142 OP e153 DO 首页10.1212/WNL.0000000000201388vo100 IS 2 A1 Smyth, Andrew A1 O'Donnell, Martin A1 Rangarajan, Sumathy A1 Hankey, Graeme J. A1 Oveisgharan, Shahram A1 Canavan, Michelle A1 McDermott, Clodagh A1 Xavier, Denis A1 Zhang, Hongye A1 Damasceno, Albertino A1 Avezum, Alvaro A1 Pogosova, Nana A1 Oguz, Aytekin A1 rygllewicz, Danuta A1 Iversen, Helle Klingenberg A1 Lanas, Fernando A1 Rosengren, Annika A1 Yusuf, Salim A1 Langhorne, Peter A1，YR 2023 UL http://n.首页neurology.org/content/100/2/e142.abstract AB背景和目标饮酒与中风之间的关系尚不确定，特别是低中度摄入量。我们在一项大型国际研究中探讨了这些联系。INTERSTROKE是一项病例对照研究，是国际上最大的急性中风危险因素研究。饮酒量自我报告，并按饮酒量/周分类为低(1-7)、中等(女性7-14，男性7-21)或高(女性>14，男性>21)。重度间歇性饮酒(HED)定义为每月至少1天饮酒5次。使用多变量条件逻辑回归来确定相关性。结果纳入12913例病例和12935例对照组;25.0% (n = 6,449)是当前饮酒者，16.7% (n = 4,318)曾经饮酒者，58.3% (n = 15,076)从不饮酒者。目前的饮酒者多为年轻、男性、吸烟、活跃且从事高薪职业的人。 Current drinking was associated with all stroke (OR 1.14; 95% CI 1.04–1.26) and intracerebral hemorrhage (ICH) (OR 1.50, 95% CI 1.21–1.84) but not ischemic stroke (OR 1.06; 95% CI 0.95–1.19). HED pattern was associated with all stroke (OR 1.39; 95% CI 1.21–1.59), ischemic stroke (OR 1.29; 95% CI 1.10–1.51), and ICH (OR 1.76; 95% CI 1.31–2.36). High level of alcohol intake was consistently associated with all stroke, ischemic stroke, and ICH. Moderate intake was associated with all stroke and ICH but not ischemic stroke. Low alcohol intake was not associated with stroke overall, but there were regional differences; low intake was associated with reduced odds of stroke in Western Europe/North America (OR 0.66; 95% CI 0.45–0.96) and increased odds in India (OR 2.18; 95% CI 1.42–3.36) (p-interaction 0.037). Wine consumption was associated with reduced odds of all stroke and ischemic stroke but not ICH. The magnitudes of association were greatest in those without hypertension and current smokers.Discussion High and moderate intake were associated with increased odds of stroke, whereas low intake was not associated with stroke. However, there were important regional variations, which may relate to differences in population characteristics of alcohol consumers, types or patterns of consumption.AHEI=Alternate Healthy Eating Index; CVD=cardiovascular disease; HED=heavy episodic drinking; ICH=intracerebral hemorrhage