TY - JOUR T1 -酒精摄入是急性卒中的危险因素JF -神经学JO -神经学SP - e142 LP - e153 DO - 10首页.1212/WNL.0000000000201388六世- 100 - 2非盟-史密斯,Andrew AU - O ' donnell,马丁盟——Rangarajan周二Sumathy盟,纸巾,格雷姆j . AU - Oveisgharan Shahram盟,Canavan米歇尔AU -麦克德莫特,Clodagh AU -泽维尔,丹尼斯•张盟——红叶盟——Damasceno Albertino盟——Avezum Alvaro AU - Pogosova,娜娜盟——它Aytekin盟——Ryglewicz Danuta盟——球队,赫勒克林根贝格AU -拉娜,费尔南多AU -罗森格林,安妮卡非盟-优素福,萨利姆盟,兰霍恩彼得盟,Y1 - 2023/01/10 UR - http://n.首页neurology.org/content/100/2/e142.abstract N2 -背景和目标饮酒与中风之间的关系尚不确定，特别是对于低中度摄入量。我们在一项大型国际研究中探讨了这些联系。INTERSTROKE是一项病例对照研究，是国际上最大的急性中风危险因素研究。饮酒量是自我报告的，并按每周饮酒量分类为低(1-7杯)、中等(女性7-14杯，男性7-21杯)或高(女性14杯，男性21杯)。重度偶发性饮酒(HED)定义为每月1天以上饮酒5次。使用多变量条件逻辑回归来确定相关性。结果纳入12913例病例和12935例对照组;25.0% (n = 6,449)是当前饮酒者，16.7% (n = 4,318)曾经饮酒者，58.3% (n = 15,076)从不饮酒者。目前的饮酒者多为年轻、男性、吸烟、活跃且从事高薪职业的人。 Current drinking was associated with all stroke (OR 1.14; 95% CI 1.04–1.26) and intracerebral hemorrhage (ICH) (OR 1.50, 95% CI 1.21–1.84) but not ischemic stroke (OR 1.06; 95% CI 0.95–1.19). HED pattern was associated with all stroke (OR 1.39; 95% CI 1.21–1.59), ischemic stroke (OR 1.29; 95% CI 1.10–1.51), and ICH (OR 1.76; 95% CI 1.31–2.36). High level of alcohol intake was consistently associated with all stroke, ischemic stroke, and ICH. Moderate intake was associated with all stroke and ICH but not ischemic stroke. Low alcohol intake was not associated with stroke overall, but there were regional differences; low intake was associated with reduced odds of stroke in Western Europe/North America (OR 0.66; 95% CI 0.45–0.96) and increased odds in India (OR 2.18; 95% CI 1.42–3.36) (p-interaction 0.037). Wine consumption was associated with reduced odds of all stroke and ischemic stroke but not ICH. The magnitudes of association were greatest in those without hypertension and current smokers.Discussion High and moderate intake were associated with increased odds of stroke, whereas low intake was not associated with stroke. However, there were important regional variations, which may relate to differences in population characteristics of alcohol consumers, types or patterns of consumption.AHEI=Alternate Healthy Eating Index; CVD=cardiovascular disease; HED=heavy episodic drinking; ICH=intracerebral hemorrhage ER -