% 0期刊文章%史密斯,安德鲁% O ' donnell,马丁% Rangarajan周二,Sumathy %纸巾,格雷姆Oveisgharan j . %, Canavan Shahram %,米歇尔·麦克德莫特%,Clodagh %泽维尔,丹尼斯%张,红叶% Damasceno, Albertino % Avezum,阿尔瓦罗·% Pogosova,娜娜%它,Aytekin % Ryglewicz, Danuta %一个球队,赫勒拉娜克林根贝格%,费尔南多%罗森格林,安妮卡%优素福,萨利姆%蓝鸿恩,彼得%,% T饮酒作为急性中风的危险因素% B INTERSTROKE研究% D R 10.1212 / WNL 2023%。0000000000201388 % J首页神经病学% P e142-e153 % V 100% N 2% X背景和目标有饮酒与中风之间的关系的不确定性,特别是对low-moderate摄入量。我们在一个大型国际研究探索了这些联系。INTERSTROKE方法,病例对照研究,是最大的国际研究急性中风的危险因素。饮酒是自我报告和分类的饮料/周低(1 - 7),中等(7 - 14为雌性和雄性7-21),或高(> 14女性>男性21日)。重度饮酒者(HED)被定义为> 5饮料≥1天/月。多变量条件逻辑回归是用来确定关联。结果包括12913例病例和12935例对照;25.0% (n = 6449)目前的饮酒者,16.7% (n = 4318)前喝酒的人,58.3% (n = 15076)从不喝酒。当前年轻饮酒者,男,吸烟者,活跃,和高薪的职业。当前饮酒与中风(或1.14;95%可信区间1.04 - -1.26)和脑出血(我)(-1.84或1.50,95% CI 1.21)但不是缺血性中风(或1.06; 95% CI 0.95–1.19). HED pattern was associated with all stroke (OR 1.39; 95% CI 1.21–1.59), ischemic stroke (OR 1.29; 95% CI 1.10–1.51), and ICH (OR 1.76; 95% CI 1.31–2.36). High level of alcohol intake was consistently associated with all stroke, ischemic stroke, and ICH. Moderate intake was associated with all stroke and ICH but not ischemic stroke. Low alcohol intake was not associated with stroke overall, but there were regional differences; low intake was associated with reduced odds of stroke in Western Europe/North America (OR 0.66; 95% CI 0.45–0.96) and increased odds in India (OR 2.18; 95% CI 1.42–3.36) (p-interaction 0.037). Wine consumption was associated with reduced odds of all stroke and ischemic stroke but not ICH. The magnitudes of association were greatest in those without hypertension and current smokers.Discussion High and moderate intake were associated with increased odds of stroke, whereas low intake was not associated with stroke. However, there were important regional variations, which may relate to differences in population characteristics of alcohol consumers, types or patterns of consumption.AHEI=Alternate Healthy Eating Index; CVD=cardiovascular disease; HED=heavy episodic drinking; ICH=intracerebral hemorrhage %U //www.ez-admanager.com/content/neurology/100/2/e142.full.pdf