@文章{Smythe142，作者= {Smyth, Andrew and O{\textquoteright}Donnell, Martin and Rangarajan, Sumathy and Hankey, Graeme J. and Oveisgharan, Shahram and Canavan, Michelle and McDermott, Clodagh and Xavier, Denis and Zhang, Hongye and Damasceno, Albertino and Avezum, Alvaro and Pogosova, Nana and Oguz, Aytekin and rygllewicz, Danuta and Iversen, Helle Klingenberg and Lanas, Fernando and Rosengren, Annika and Yusuf, Salim and Langhorne, Peter and，}，title ={酒精摄入是急性脑卒中的危险因素}，volume = {100}， number = {2}， pages = {e142—e153}， year = {2023}， doi = {10.1212/WNL。0000000000201388}，出版商= {Wolters Kluwer健康公司代表美国神经病学学会}，摘要={背景和目标饮酒与中风之间的关系尚不确定，特别是对于低中度摄入量。首页我们在一项大型国际研究中探讨了这些联系。INTERSTROKE是一项病例对照研究，是国际上最大的急性中风危险因素研究。饮酒量自我报告，并按饮酒量/周分类为低(1{\textendash}7)、中等(女性7{\textendash}14，男性7{\textendash}21)或高(女性\>14，男性\>21)。重度间歇性饮酒(HED)定义为每月>=1天喝5杯。使用多变量条件逻辑回归来确定相关性。结果纳入12913例病例和12935例对照组;25.0\% (n = 6,449)是当前饮酒者，16.7% (n = 4,318)曾经饮酒者，58.3% (n = 15,076)从不饮酒者。目前的饮酒者多为年轻、男性、吸烟、活跃且从事高薪职业的人。 Current drinking was associated with all stroke (OR 1.14; 95\% CI 1.04{\textendash}1.26) and intracerebral hemorrhage (ICH) (OR 1.50, 95\% CI 1.21{\textendash}1.84) but not ischemic stroke (OR 1.06; 95\% CI 0.95{\textendash}1.19). HED pattern was associated with all stroke (OR 1.39; 95\% CI 1.21{\textendash}1.59), ischemic stroke (OR 1.29; 95\% CI 1.10{\textendash}1.51), and ICH (OR 1.76; 95\% CI 1.31{\textendash}2.36). High level of alcohol intake was consistently associated with all stroke, ischemic stroke, and ICH. Moderate intake was associated with all stroke and ICH but not ischemic stroke. Low alcohol intake was not associated with stroke overall, but there were regional differences; low intake was associated with reduced odds of stroke in Western Europe/North America (OR 0.66; 95\% CI 0.45{\textendash}0.96) and increased odds in India (OR 2.18; 95\% CI 1.42{\textendash}3.36) (p-interaction 0.037). Wine consumption was associated with reduced odds of all stroke and ischemic stroke but not ICH. The magnitudes of association were greatest in those without hypertension and current smokers.Discussion High and moderate intake were associated with increased odds of stroke, whereas low intake was not associated with stroke. However, there were important regional variations, which may relate to differences in population characteristics of alcohol consumers, types or patterns of consumption.AHEI=Alternate Healthy Eating Index; CVD=cardiovascular disease; HED=heavy episodic drinking; ICH=intracerebral hemorrhage}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/2/e142}, eprint = {//www.ez-admanager.com/content/100/2/e142.full.pdf}, journal = {Neurology} }