% 0期刊文章%一个Ryul金正日% Seohee Choi % Kyeongho Byun % Nyeonju Kang %一个年轻Ju Suh % Jin-Sun君% Beomseok全% T协会早期帕金森病的患者体重变化与认知下降% D R 10.1212 / WNL 2023%。0000000000201404 % J首页神经病学% P e232-e241 % V 100% N 2% X背景和客观检查是否早期体重变化与随后的认知功能下降有关,包括整体性能和特定的域,在帕金森病(PD)。方法观察研究使用的数据从帕金森进展标记主动队列。病人接受年度nonmotor评估神经精神、睡眠、自主症状长达8年的随访。使用蒙特利尔认知评估认知功能测定(MoCA)和详细的神经心理测试。线性mixed-effects模型应用于调查协会的早期体重变化与纵向演化的认知和其他nonmotor症状。结果共有358例早期PD患者分为减肥(> 3%体重的减少在第一年;n = 98)、体重(在±3%;n = 201)、和体重增加(增加> 3%;n = 59)组。减肥组显示更快下降MoCA分数比体重组(β=−0.19,95% CI 0.28−−0.10)。对特定的认知领域,减肥组显示语义流畅陡峭下降考试成绩(β=−0.37,95% CI 0.66−−0.08)和MoCA音韵流畅性测试成绩(β=−0.18,95% CI 0.31−−0.05),并在较小程度上,Letter-Number测序分数(β=−0.07,95% CI 0.14−0.01)相比,体重组。 Conversely, the weight gain group showed a slower decline in the Symbol Digit Modalities Test scores (β = 0.34, 95% CI 0.05 to 0.63), although no association was found with longitudinal changes in MoCA scores. We did not find any significant effects of weight change on the progression of other nonmotor symptoms.Discussion Early weight loss was associated with a faster progression of decline in global cognitive function and executive function in patients with PD, whereas early weight gain was associated with a slower progression of decline in processing speed and attention. The impact of early weight change on nonmotor symptoms seemed to be specific to cognition.BJLO=Benton Judgment of Line Orientation; BMI=body mass index; ESS=Epworth Sleepiness Scale; GDS=Geriatric Depression Scale; HVLT=Hopkins Verbal Learning Test; LNS=Letter-Number Sequencing; MoCA=Montreal Cognitive Assessment; MMSE=Mini-Mental State Examination; PD=Parkinson disease; PPMI=Parkinson Progression Markers Initiative; RBDSQ=REM Sleep Behavior Disorder Screening Questionnaire; SCOPA-AUT=Scale for Outcomes in Parkinson disease-Autonomic; SDMT=Symbol Digit Modalities Test; SFT=Semantic Fluency Test %U //www.ez-admanager.com/content/neurology/100/2/e232.full.pdf