[j] .饮食习惯与20年期间中年痴呆发病率的关系[j] .神经病学[j] .神经病学SP - e28 LP - e37 DO . 10.1212/WNL.0000000000201336。首页六世- 100 - 1 AU -龟头,伊莎贝尔盟——Sonestedt,艾米丽盟——Nagga凯蒂盟——Gustavsson Anna-Marta AU - Gonzalez-Padilla,以斯帖盟——承担,燕盟——Stomrud Erik AU -米蓝德奥尔AU -尼尔森,Peter m . AU - Palmqvist塞巴斯蒂安AU -汉森,奥斯卡·Y1 - 2023/01/03 UR - //www.ez-admanager.com/content/100/1/e28.abstract N2 -背景和目标痴呆病例预计三在接下来的30年里,首页强调发现可改变的痴呆症风险因素的重要性。本研究的目的是调查坚持传统饮食建议或改良地中海饮食是否与随后发生全因痴呆、阿尔茨海默病(AD)、血管性痴呆(VaD)的风险降低或与AD相关的β-淀粉样蛋白(a β)病理的未来积累有关。方法1991-1996年对前瞻性瑞典人群Malmö饮食与癌症研究进行基线检查，随访至2014年痴呆事件。出生于1923-1950年，居住在Malmö的非痴呆人士被邀请参加。招募了三万四千四十六人(占所有合格人员的41%)。28,25人有饮食数据并被纳入了这项研究。通过7天饮食日记、详细的食物频率问卷和1小时的访谈来评估饮食习惯。主要结局是由记忆诊所医生确定的偶发性全因痴呆、AD或VaD。次要终点是使用CSF a - β42测量a - β积累(n = 738)。 Cox proportional hazard models were used to examine associations between diet and risk of developing dementia (adjusted for demographics, comorbidities, smoking, physical activity, and alcohol).Results Sixty-one percent were women, and the mean (SD) age was 58.1 (7.6) years. One thousand nine hundred forty-three (6.9%) were diagnosed with dementia (median follow-up, 19.8 years). Individuals adhering to conventional dietary recommendations did not have lower risk of developing all-cause dementia (hazard ratio [HR] comparing worst with best adherence, 0.93, 95% CI 0.81–1.08), AD (HR 1.03, 0.85–1.23), or VaD (HR 0.93, 0.69–1.26). Neither did adherence to the modified Mediterranean diet lower the risk of developing all-cause dementia (HR 0.93 0.75–1.15), AD (HR 0.90, 0.68–1.19), or VaD (HR 1.00, 0.65–1.55). The results were similar when excluding participants developing dementia within 5 years or those with diabetes. No significant associations were found between diet and abnormal Aβ accumulation, conventional recommendations (OR 1.28, 0.74–2.24) or modified Mediterranean diet (OR 0.85, 0.39–1.84).Discussion In this 20-year follow-up study, neither adherence to conventional dietary recommendations nor to modified Mediterranean diet were significantly associated with subsequent reduced risk for developing all-cause dementia, AD dementia, VaD, or AD pathology.Aβ=AD-related β-amyloid; AD=Alzheimer disease; FFQ=food frequency questionnaire; mMDS=modified Mediterranean diet score; IQR=interquartile range; METhh/week=metabolic equivalent hours/week; NPR=National Patient Register; PREDIMED=Prevención con Dieta Mediterránea; SDGS=Swedish dietary guidelines score; VaD=vascular dementia ER -