TY - T1的饮食习惯之间的关系在20年内中年与老年痴呆发病率的JF -神经学乔-神经病学SP - e28 LP - e37做- 10.1212 / WNL。首页0000000000201336六世- 100 - 1 AU -龟头,伊莎贝尔盟——Sonestedt,艾米丽盟——Nagga凯蒂盟——Gustavsson Anna-Marta AU - Gonzalez-Padilla,以斯帖盟——承担,燕盟——Stomrud Erik AU -米蓝德,大车AU -尼尔森,Peter m . AU - Palmqvist塞巴斯蒂安AU -汉森,奥斯卡·Y1 - 2023/01/03 UR - //www.ez-admanager.com/content/100/1/e28.abstract N2 -背景和目标痴呆病例预计三在接下来的30年里,强调发现修改的痴呆的风险因素的重首页要性。本研究的目的是调查是否坚持传统膳食的建议或者修改地中海饮食与后续发展中全因老年痴呆症的风险降低,阿尔茨海默病(AD)、血管性痴呆(VaD),或与未来积累AD-relatedβ-amyloid (Aβ)病理。方法基线检查潜在的瑞典马尔默以人群为基础的饮食和癌症研究发生在1991 - 1996年的后续事件直到2014年痴呆。Nondemented个人出生1923 - 1950和生活在马尔默应邀参加。三万零四百四十六年招募(41%的资格)。二万八千零二十五年饮食数据,并纳入本研究。饮食习惯进行评估与7天的食物日记,详细的食物频率问卷,小时的采访。主要结果是事件全因痴呆、广告或通过由记忆诊所的医生。二次使用CSF Aβ42 Aβ-accumulation测量结果(n = 738)。Cox比例风险模型被用来研究饮食与患痴呆症的风险之间的关联(调整人口结构,并存病,吸烟,体育活动,和酒精)。结果百分之六十一是女性,平均为58.1(7.6)岁(SD)。 One thousand nine hundred forty-three (6.9%) were diagnosed with dementia (median follow-up, 19.8 years). Individuals adhering to conventional dietary recommendations did not have lower risk of developing all-cause dementia (hazard ratio [HR] comparing worst with best adherence, 0.93, 95% CI 0.81–1.08), AD (HR 1.03, 0.85–1.23), or VaD (HR 0.93, 0.69–1.26). Neither did adherence to the modified Mediterranean diet lower the risk of developing all-cause dementia (HR 0.93 0.75–1.15), AD (HR 0.90, 0.68–1.19), or VaD (HR 1.00, 0.65–1.55). The results were similar when excluding participants developing dementia within 5 years or those with diabetes. No significant associations were found between diet and abnormal Aβ accumulation, conventional recommendations (OR 1.28, 0.74–2.24) or modified Mediterranean diet (OR 0.85, 0.39–1.84).Discussion In this 20-year follow-up study, neither adherence to conventional dietary recommendations nor to modified Mediterranean diet were significantly associated with subsequent reduced risk for developing all-cause dementia, AD dementia, VaD, or AD pathology.Aβ=AD-related β-amyloid; AD=Alzheimer disease; FFQ=food frequency questionnaire; mMDS=modified Mediterranean diet score; IQR=interquartile range; METhh/week=metabolic equivalent hours/week; NPR=National Patient Register; PREDIMED=Prevención con Dieta Mediterránea; SDGS=Swedish dietary guidelines score; VaD=vascular dementia ER -
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