@文章{Glanse28，作者= {Glans, Isabelle和Sonestedt, Emily和N{\"a}gga, Katarina和Gustavsson, Anna-M{'a} rta和Gonz{\'a}lez-Padilla, Esther和Borne, Yan和Stomrud, Erik和Melander, Olle和Nilsson, Peter M.和Palmqvist, Sebastian和Hansson, Oskar}，标题={中年饮食习惯与痴呆症发病率之间的关系在20年期间}，卷={100}，数字={1}，页数= {e28—e37}，年份= {2023}，doi = {10.1212/WNL。0000000000201336}，出版商= {Wolters Kluwer Health, Inc.代表美国神经病学学会}，摘要={背景和目标痴呆症病例预计在未来30年内增加两倍，突出了寻找痴首页呆症可改变的风险因素的重要性。本研究的目的是调查坚持传统饮食建议或改良的地中海饮食是否与随后发生全因痴呆、阿尔茨海默病(AD)、血管性痴呆(VaD)的较低风险相关，或与AD相关β-淀粉样蛋白(a β)病理的未来积累相关。方法在1991年至1996年的前瞻性瑞典马尔姆饮食和癌症研究中进行基线检查，并对痴呆事件进行随访至2014年。1923年出生、1950年居住在马尔姆的非痴呆患者被邀请参与研究。招募了3万446人(占所有合格人员的41%)。28,25人有饮食数据并被纳入这项研究。通过7天的饮食日记、详细的饮食频率问卷和1小时的访谈来评估饮食习惯。主要结局是由记忆临床医生确定的偶发全因痴呆、AD或VaD。次要终点是用脑脊液Aβ42测定a β积累(n = 738)。Cox比例风险模型用于检验饮食与痴呆症发病风险之间的相关性(根据人口统计学、共病、吸烟、体育活动和酒精进行了调整)。结果女性占61%，平均年龄为58.1(7.6)岁。一千九百四十三人(6.9%)被诊断为痴呆症(平均随访19.8年)。 Individuals adhering to conventional dietary recommendations did not have lower risk of developing all-cause dementia (hazard ratio [HR] comparing worst with best adherence, 0.93, 95\% CI 0.81{\textendash}1.08), AD (HR 1.03, 0.85{\textendash}1.23), or VaD (HR 0.93, 0.69{\textendash}1.26). Neither did adherence to the modified Mediterranean diet lower the risk of developing all-cause dementia (HR 0.93 0.75{\textendash}1.15), AD (HR 0.90, 0.68{\textendash}1.19), or VaD (HR 1.00, 0.65{\textendash}1.55). The results were similar when excluding participants developing dementia within 5 years or those with diabetes. No significant associations were found between diet and abnormal Aβ accumulation, conventional recommendations (OR 1.28, 0.74{\textendash}2.24) or modified Mediterranean diet (OR 0.85, 0.39{\textendash}1.84).Discussion In this 20-year follow-up study, neither adherence to conventional dietary recommendations nor to modified Mediterranean diet were significantly associated with subsequent reduced risk for developing all-cause dementia, AD dementia, VaD, or AD pathology.Aβ=AD-related β-amyloid; AD=Alzheimer disease; FFQ=food frequency questionnaire; mMDS=modified Mediterranean diet score; IQR=interquartile range; METhh/week=metabolic equivalent hours/week; NPR=National Patient Register; PREDIMED=Prevenci{\'o}n con Dieta Mediterr{\'a}nea; SDGS=Swedish dietary guidelines score; VaD=vascular dementia}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/1/e28}, eprint = {//www.ez-admanager.com/content/100/1/e28.full.pdf}, journal = {Neurology} }