PT -期刊文章盟Koji Kamagata AU -克里斯蒂娜Andica盟Kaito Takabayashi AU - Yuya Saito盟Toshiaki Taoka AU - Hayato Nozaki盟Junko Kikuta AU - Shohei Fujita盟Akifumi Hagiwara AU - Kouhei Kamiya AU - Akihiko和田AU - Toshiaki明石盟Sano大友盟第三Nishizawa盟——渡边Hori AU -真嗣Naganawa盟盟青木Shigeki -阿尔茨海默病的神经影像学的TI - MRI协会指数Glymphatic系统与淀粉样蛋白沉积轻度认知障碍和阿尔茨海默病的认知[j] . doi: 10.1212/WNL.0000000000201300DP - 2022 12月13日TA - N首页eurology PG - e2648—e2660 VI - 99 IP - 24 4099 - //www.ez-admanager.com/content/99/24/e2648.short 4100 - //www.ez-admanager.com/content/99/24/e2648.full SO - Neurology2022 12月13日;背景和目的淋巴系统是一个全脑血管周围网络，促进脑脊液/间质液交换。该系统的改变可能在β淀粉样蛋白(a β)积累中起关键作用。然而，其与阿尔茨海默病(AD)发病机制的关系尚不完全清楚。在这里，我们研究了与轻度认知障碍(MCI)和AD患者血管周围网络相关的无创MRI测量的变化。此外，我们还探讨了MRI测量与神经心理学评分、PET标准化摄取值比(SUVR)和Aβ沉积的关系。方法比较来自阿尔茨海默病神经影像学倡议数据库的MCI患者、AD患者和健康对照者的MRI测量，包括血管周围空间(PVS)体积分数(PVSVF)、白质游离水分数体积(FW-WM)和血管周围空间扩散指数(ALPS指数)。在MCI和AD患者的联合亚队列中，MRI测量也与脑脊液生物标志物、PET SUVR和认知评分水平相关。 Statistical analyses were performed with age, sex, years of education, and APOE status as confounding factors.Results In total, 36 patients with AD, 44 patients with MCI, and 31 healthy controls were analyzed. Patients with AD had significantly higher total, WM, and basal ganglia PVSVF (Cohen d = 1.15–1.48; p < 0.001) and FW-WM (Cohen d = 0.73; p < 0.05) and a lower ALPS index (Cohen d = 0.63; p < 0.05) than healthy controls. Meanwhile, the MCI group only showed significantly higher total (Cohen d = 0.99; p < 0.05) and WM (Cohen d = 0.91; p < 0.05) PVSVF. Low ALPS index was associated with lower CSF Aβ42 (rs = 0.41, pfdr = 0.026), FDG-PET uptake (rs = 0.54, pfdr < 0.001), and worse multiple cognitive domain deficits. High FW-WM was also associated with lower CSF Aβ42 (rs = −0.47, pfdr = 0.021) and worse cognitive performances.Discussion Our study indicates that changes in PVS-related MRI parameters occur in MCI and AD, possibly due to impairment of the glymphatic system. We also report the associations between MRI parameters and Aβ deposition, neuronal change, and cognitive impairment in AD.Aβ=amyloid β; ADAS=Alzheimer's Disease Assessment Scale; ADNI=Alzheimer's Disease Neuroimaging Initiative; ALPS=diffusivity along the perivascular space; BG=basal ganglia; CDR-SB=Clinical Dementia Rating Scale Sum of Boxes; DBP=diastolic blood pressure; DTI=diffusion tensor imaging; DW=diffusion weighted; FA=fractional anisotropy; FAQ=Functional Activities Questionnaire; FDG=[18F] fluorodeoxyglucose; FLAIR=fluid-attenuated inversion recovery; FSL=FMRIB Software Library 6.0.3; FW=free water; GBCA=gadolinium-based contrast agent; GMVF=gray matter volume fraction; Hipp=hippocampus; HMSCORE=Modified Hachinski Ischemic Score; ISF=interstitial fluid; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; PVS=perivascular space; PVSVF=PVS volume fraction; RAVLT=Rey Auditory Verbal Learning Test; ROI=region of interest; SBP=systolic blood pressure; SUVR=standardized uptake value ratio; T1w=T1 weighted; WM=white matter; WML=white matter lesion; WMLVF=white matter lesion volume fraction; WMVF=white matter volume fraction