TY - T1的初次免疫失调在亚急性硬化性全脑炎:一项病例对照研究摩根富林明-神经学乔-神经病学SP - S48 LP - S49做wnl.0000903396.99709 10.1212/01.。首页aa六世- 99 - 23补充2盟Vijay Varman Malhotra盟盟- Vinay Suresh盟Hardeep - Neeraj Kumar说盟Ravindra加戈Y1 - 2022/12/05 UR - //www.ez-admanager.com/content/99/23_Supplement首页_2/S48.2.abstract N2 -目的主要目标是研究免疫失调的模式例亚急性硬化性全脑炎(SSPE)。二级目标是评估测量免疫变量之间的相关性和残疾/死亡在6个月时,背景SSPE是一种慢性进行性神经病学方面的疾病引起的有缺陷的麻疹病毒。它是假定免疫失调可能导致持续感染(免疫逃避)以及启动自身免疫现象(通过自然杀伤细胞)导致全脑炎。设计/方法这是一个前瞻性研究tertiary-case referral-facility从2020年1月到2021年9月。连续30个病人履行Dyken SSPE的标准和30 age-and-sex-matched健康对照组被录取。免疫分析概要文件由淋巴细胞产生子集,免疫球蛋白水平和补充水平在所有情况下,控制。例按Jabbour上演的系统;残疾评估使用改良Rankin规模(夫人)。结果患者SSPE的平均年龄14.76岁(±6.9年)。有25个男性和5女性; 6.7% cases belonged to Jabbour's first stage, 40% to second stage and 53.3% to third stage. Levels of absolute lymphocyte count, B-cells, T cells, helper T-cells and cytotoxic T-cells were significantly higher in cases. IgG, IgM and IgE levels were significantly higher while IgD levels were significantly lower in cases. At baseline, 13.3% of cases had a mRS score of 0-2 and 86.7% had a score of 3-6; at 6 months 10% had a mRS score 0-2 (favorable outcome) while 90% had a mRS score 3-6 (poor outcome). No correlation of immunological parameters with outcome was found.Conclusions Significant immune dysregulation in terms of lymphocyte subsets and immunoglobulin levels seem to exist in SSPE. These findings may pave way for targeted immunomodulator therapy that can be targeted in a larger cohort of patients. ER -