% 0期刊文章%一个Vijay Varman % Vinay Suresh % Hardeep Malhotra %一个Ravindra Garg Neeraj Kumar说% % T初次免疫失调在亚急性硬化性全脑炎:病例对照研究% D R 10.1212/01. wnl.0000903396.99709 2022%。aa % J首页神经病学% P S48-S49 % V 99% N 23补充2% X目的主要目标是研究免疫失调的模式例亚急性硬化性全脑炎(SSPE)。二级目标是评估测量免疫变量之间的相关性和残疾/死亡在6个月时,背景SSPE是一种慢性进行性神经病学方面的疾病引起的有缺陷的麻疹病毒。它是假定免疫失调可能导致持续感染(免疫逃避)以及启动自身免疫现象(通过自然杀伤细胞)导致全脑炎。设计/方法这是一个前瞻性研究tertiary-case referral-facility从2020年1月到2021年9月。连续30个病人履行Dyken SSPE的标准和30 age-and-sex-matched健康对照组被录取。免疫分析概要文件由淋巴细胞产生子集,免疫球蛋白水平和补充水平在所有情况下,控制。例按Jabbour上演的系统;残疾评估使用改良Rankin规模(夫人)。结果患者SSPE的平均年龄14.76岁(±6.9年)。有25个男性和5女性;6.7%的情况下属于Jabbour的第一阶段,40%为第三阶段第二阶段和53.3%。 Levels of absolute lymphocyte count, B-cells, T cells, helper T-cells and cytotoxic T-cells were significantly higher in cases. IgG, IgM and IgE levels were significantly higher while IgD levels were significantly lower in cases. At baseline, 13.3% of cases had a mRS score of 0-2 and 86.7% had a score of 3-6; at 6 months 10% had a mRS score 0-2 (favorable outcome) while 90% had a mRS score 3-6 (poor outcome). No correlation of immunological parameters with outcome was found.Conclusions Significant immune dysregulation in terms of lymphocyte subsets and immunoglobulin levels seem to exist in SSPE. These findings may pave way for targeted immunomodulator therapy that can be targeted in a larger cohort of patients. %U //www.ez-admanager.com/content/neurology/99/23_Supplement_2/S48.2.full.pdf