TY -的T1的MOG Antibody-Associated疾病复发性脑皮质脑炎JF -神经学乔-神经病学SP - S19 LP - S20做wnl.0000903180.06286 10.1212/01.。首页英航六世- 99 - 23补充2非盟-劳拉Cacciaguerra AU -约翰·j·陈盟Eoin p·弗拉纳根Y1 - 2022/12/05 UR - //www.ez-admanager.com/content/99/23_Supplement_2首页/S19.abstract N2 -客观NA。背景脑皮质脑炎是一种最近公认的myelin-oligodendrocyte-glycoprotein-antibody-associated综合症疾病(MOGAD),然而大多数报告描述单一事件没有复发。设计/方法病例报告的复发性脑皮质MOGAD脑炎。结果这是一个32岁的病人的病例报告最初发达脑膜脑炎在他三岁的时候。他稳定直到31岁,当他发达头痛其次是癫痫持续状态二次脑皮质脑炎伴随单边右颞脑皮质T2-hyperintensity leptomeningeal增强。脑脊液分析显示505白细胞/µl(正常,0 - 5),但寡克隆乐队是负面的。在随后的两个星期他发达国严重视力丧失双边(20/400)伴随着双边视神经盘水肿、轨道和MRI显示两国前段视神经增强扩展在每个神经的长度的50%,确认两国视神经炎。MOG-IgG测试在血清和积极的1:10 0的效价。他是用静脉注射甲基强的松龙治疗连续5天每天1克,随后缓慢与levetiracetam口服强的松锥度的抗癫痫治疗,后来转换到奥卡西平,尽管他后来self-discontinued所有的抗癫痫。他收到维修静脉注射免疫球蛋白(丙种球蛋白)每周0.4 g / Kg,后来断奶每4周1克/公斤。 He then developed recurrent cerebral cortical encephalitis 18 months after his prior episode manifesting with seizures and left occipito-temporal T2-hyperintensity and swelling with leptomeningeal enhancement. He was treated with high dose IV steroids, an oral prednisone taper and his IVIg dose was changed back to 0.4 g/Kg once weekly and anti-seizure medications reinitiated.Conclusions Cerebral cortical encephalitis in MOGAD can be recurrent. Close scrutiny of the MRI in patients with MOGAD who develop seizures after prior cerebral cortical encephalitis is important as it can discriminate a recurrent cerebral cortical encephalitis attack from a breakthrough seizure related to prior damage. ER -