TY -的T1 -类固醇Un-Responsive脑病与自身免疫性甲状腺炎(SUEAT)在儿科患者。摩根富林明首页-神经学乔-神经病学SP - S44 LP - S44做wnl.0000903348.35087 10.1212/01.。a1六世- 99 - 23补充2盟Geetanjali拉索尔教授Y1 - 2022/12/05 UR - //www.ez-admanager.com/content/99首页/23_Supplement_2/S44.1.abstract N2 -目标我们报告的一系列脑病患儿伴有甲状腺抗体耐火类固醇单药治疗。背景类固醇响应性脑病与自身免疫性甲状腺炎(SREAT)是一种罕见的疾病,只有几个孤立的儿童病例报道。用类固醇治疗后,临床明显改善是SREAT的一个标志。Design/Methods An IRB approved chart review was conducted on patients <18 years diagnosed with autoimmune encephalitis. A retrospective analysis of clinical features, diagnostic tests, response to therapy and long term follow up was conducted on patients positive for Thyroperoxidase (TPO) antibodies.Results 52 patients <18 years were diagnosed with autoimmune encephalitis, 10 (19.2%) of these were positive for TPO antibodies. Median age at disease onset was 14.5 years (range 6-18 years) with only 1 male patient being. Mental status (90%) and behavior changes (100%) were most common presentations, seizures were detected in only 1 patient. MRI (20%) and EEG (30%) abnormalities were uncommon, and only 1 patient had evidence of inflammation in cerebrospinal fluid (CSF). Autoimmune encephalitis and paraneoplastic antibody panels were negative besides 2 (20%) patients having concomitant Thyroglobulin (TG) antibodies. All patients needed additional IVIG after steroids treatment, 7 (70%) patients received Rituximab and 3 (30%) patients needed Plasmapheresis. All patients recovered at an average of 4.4 years follow up.Conclusions Encephalopathy associated with thyroid antibodies can be steroid unresponsive in the pediatric population. Further immune therapy, including plasmapheresis, should be considered in these patients, even in the absence of other para-clinical evidence of inflammation. ER -