% 0期刊文章%一个汉娜Zhao-Fleming % Anza Zahid %通陆%小菁太阳%一个肖恩Pittock % Hon-Chi李% Divyanshu Dubey % T表征心脏Bradyarrhythmia与LGI1-IgG自身免疫性脑炎% D 2022% R 10.1212/01. wnl.0000903124.01060.58 % J神经病学% P S13-S13 % V 99% N 23补充2% X客观评价和描述心律失常与LGI1-IgG(富亮氨酸脑胶质瘤灭活1-IgG)自身免疫性脑炎(AE)。首页背景AE越来越确定为一个潜在的治疗引起的脑炎。LGI1-IgG是最常见的一种神经特定致病与成人AE相关自身抗体。之前bradyarrhythmias和猝死病例已报告在LGI1-IgG AE,然而,更大的群组研究缺乏。设计/方法回顾性的描述性研究,我们确定了梅奥诊所的病人(2008年5月1日- 2020年12月31日)与LGI1-IgG AE曾心电图证实bradyarrhythmias在最初的演示。入选标准是1)LGI1-IgG积极性具有一致的临床综合征;2)心电图描记的bradyarrhythmia的证据;和3)足够的临床资料。我们排除了患者bradyarrhythmias交替的原因。我们收集人口/临床资料包括的细节bradyarrhythmia(严重程度、持续时间、治疗),和神经系统和心脏的结果。结果我们发现患者LGI1-IgG AE bradyarrhythmia 8%的频率在最初的演示。bradyarrhythmia是通常无症状(6/11,55%); however, the episode was severe with one patient requiring a pacemaker. Outcome was also generally favorable with the majority (8/11, 73%) having full resolution without further cardiac intervention. Lastly, we found that mouse and human cardiac tissues express LGI1 (mRNA and protein), suggesting that LGI1-IgG may influence cardiac tissue itself.Conclusions LGI1-IgG AE can be rarely associated with bradyarrhythmias. Although the disease course is mostly favorable, some cases may require pacemaker placement to avoid devastating outcomes. %U //www.ez-admanager.com/content/neurology/99/23_Supplement_2/S13.1.full.pdf

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