PT -期刊文章盟是一家Lalwani盟——我。M Thushara AU - Sudheeran Kannoth AU - Anand Kumar盟Vivek Nambiar盟Sibi Gopinath AU - Udit Saraf AU - Annamma吉拉盟Dayana安东尼TI -第一个病例报告的AMPA受体脑炎有帕金森症援助的特点- 10.1212/01. wnl.0000903356.12164.0d DP - 2022 12月05 TA -神经病学PG - S44 S45 VI - 99 IP - 23补充2 4099 - //www.ez-admanager.com/content/99/23_Supplement_2/S首页44.3.short 4100 - //www.ez-admanager.com/content/99/23_Supplement_2/S44.3.full所以Neurology2022 12月05;99 AB -客观NA。背景自身免疫性脑炎是一种大脑的炎症状态,由于抗体onconeuronal蛋白质。多种的帕金森症非常罕见。我们报告的第一例AMPA受体脑炎有帕金森症的症状,一个罕见的典型表现。设计/方法NA。结果一个71岁的女性与多个并发症在昏迷状态抱怨隐性发病缓慢进步的近期记忆障碍,进步缓慢在执行日常活动,无法沟通,和急性尿失禁发作。中枢神经系统检查最初显示的GCS E2V1M4 2级的四肢僵硬。MRI显示大脑微妙的T2天赋hyperintensities peri-ventricular和皮层下白质。血清和CSF研究显示AMPA 1抗体积极性。 The FDG PET showed an avid speculated soft tissue density lesion in the upper inner quadrant of the right breast with active right axillary lymph nodes (Histopathology- Infiltrating duct carcinoma Grade 2 NST T2N2aMx). The patient was managed using IVIg and steroids following which her sensorium improved to a GCS of E4M6V5. UPDRS at this point was 29. She subsequently underwent therapy for her tumor following which there was a significant decrease in parkinsonian symptoms and an improvement in memory without the use of any antiparkinsonian medications (UPDRS score-6). During the four years of follow-up, she has remained independent and can perform all her activities of daily living. Hence this autoimmune encephalitis case can be classified as a definite paraneoplastic neurological syndrome (PNS Care score-9).Conclusions We propose that Parkinsonism, in our case, is probably a paraneoplastic neurological syndrome associated with antibodies against the AMPA receptor, as the symptoms and signs recovered with cancer treatment.

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