是一家高级Lalwani % % 0期刊文章%一个我。M Thushara % Sudheeran Kannoth %一个Vivek Nambiar Anand Kumar % % % Sibi Gopinath一Udit Saraf %一个Dayana安东尼Annamma吉拉% % T首例报告AMPA受体脑炎有帕金森症的特点% D 2022% R 10.1212/01. wnl.0000903356.12164.0d % J神经病学% P S44-S45 % V 99% N 23补充2% X客观NA。首页背景自身免疫性脑炎是一种大脑的炎症状态,由于抗体onconeuronal蛋白质。多种的帕金森症非常罕见。我们报告的第一例AMPA受体脑炎有帕金森症的症状,一个罕见的典型表现。设计/方法NA。结果一个71岁的女性与多个并发症在昏迷状态抱怨隐性发病缓慢进步的近期记忆障碍,进步缓慢在执行日常活动,无法沟通,和急性尿失禁发作。中枢神经系统检查最初显示的GCS E2V1M4 2级的四肢僵硬。MRI显示大脑微妙的T2天赋hyperintensities peri-ventricular和皮层下白质。血清和CSF研究显示AMPA 1抗体积极性。FDG PET显示一个狂热的推测软组织密度病变在上层内象限的右乳房有积极正确的腋窝淋巴结(组织病理学-浸润导管癌2级望远镜T2N2aMx)。病人管理使用丙种球蛋白和类固醇后她感觉中枢的GCS E4M6V5改善。 UPDRS at this point was 29. She subsequently underwent therapy for her tumor following which there was a significant decrease in parkinsonian symptoms and an improvement in memory without the use of any antiparkinsonian medications (UPDRS score-6). During the four years of follow-up, she has remained independent and can perform all her activities of daily living. Hence this autoimmune encephalitis case can be classified as a definite paraneoplastic neurological syndrome (PNS Care score-9).Conclusions We propose that Parkinsonism, in our case, is probably a paraneoplastic neurological syndrome associated with antibodies against the AMPA receptor, as the symptoms and signs recovered with cancer treatment. %U //www.ez-admanager.com/content/neurology/99/23_Supplement_2/S44.3.full.pdf