TY -的T1 -测试n型电压门控钙通道抗体有限效用评估疑似Lambert-Eaton患者肌无力的症状JF -神经学乔-神经病学SP - S31 LP - S32做10.1212/01. wnl.0000903272.62514.70六世- 99 - 23补充2非盟- Masoud马吉德盟阿纳斯塔西娅Zekeridou AU -万带兰列侬首页AU -肖恩Pittock盟-安德鲁·麦肯AU -克里斯托弗·克莱因盟Dubey Divyanshu AU -约翰·米尔斯Y1 - 2022/12/05 UR - //www.ez-admanager.com/content/99/23_Supplement_2/S31.2.abstract N2 -目标来确定测试n型电压门控钙通道抗体提高血清学诊断性能测试Lambert-Eaton肌无力的综合症。背景疑似患者自身免疫神经肌肉接点传播疾病通常检测P / Q型(VGCC-P / Q)和n型(VGCC-N)电压门控钙通道抗体援助的诊断Lambert-Eaton肌无力的症状(氨基酸)。设计/方法回顾性横断面研究包括93例诊断在梅奥诊所的问题基于电诊法的发现,临床表现和积极的血清学VGCC-P / Q和/或VGCC-N。结果45例患者(48.4%)是女性,平均年龄61岁(范围11 - 99)。Twenty-five (26.9%) were positive for both VGCC antibody types (reference interval <0.04 nmol/L [VGCC-N] and <0.03 nmol/L [VGCC-P/Q]); 67 (72.0%) were positive for VGCC-P/Q only and one (1.1%) was positive for VGCC-N only. The single VGCC-N positive only result [VGCC-N = 0.10 nmol/L; VGCC-PQ = 0.02 nmol/L] was from a patient with classic LEMS presentation and no evidence of malignancy by Chest CT. The prevalence of VGCC-N only positivity was lower than in the healthy population or other disease control populations. VGCC-P/Q antibody titers were higher in patients who had detectable co-existing VGCC-N antibody (median titer 1.58 versus 0.39 nmol/L, P = 0.02) and there was a positive correlation (r = 0.762, P < 0.001) between VGCC-N and VGCC-P/Q titers in double positive cases. Dual positivity did not significantly increase the likelihood of an underlying cancer (40.9% versus 30.1%, P = 0.33).Conclusions Testing for VGCC-P/Q antibodies alone is sufficient in the serological evaluation of suspected LEMS cases. Inclusion of VGCC-N antibody testing does not improve diagnostic performance. A positive VGCC-N antibody did not significantly increase the risk of paraneoplastic LEMS. ER -