RT期刊文章SR电子T1自身免疫性脑炎的长期精神病症状缓解摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP S50 OP S50 10.1212/01. wnl.0000903首页408.52359.84 VO 99 23补充2 A1 Ramy Gabarin A1朱利安赫伯特A1 Seth Climans A1亚历山德拉Muccilli A1悉尼李A1 Gregory天A1理查德Wennberg A1大卫Tang-Wai年2022 UL //www.ez-admanager.com/content/99/23_Supplement_2/S50.1.abstract AB客观识别自我抑郁和焦虑症状的患病率在缓解患者自身免疫性脑炎(AE)。背景虽然之前研究发现高患病率的残余认知障碍患者在缓解AE,有一个缺乏这类患者长期精神结果数据。在正常人群,中位数病人健康Questionaire-9 (PHQ9)和一般焦虑Disorder-7 (GAD7)分数据报道,分别为3和2左右,与抑郁和焦虑症状的患病率在这些问卷调查报告为24%和23%左右。设计/方法回顾性横断面队列研究在三级中心AE诊所在2012-01-01和2012-01-01之间。患者通过电话联系或定期随访和PHQ9和GAD7完成。结果41例患者联系;29(71%)和包括回应。17(59%)是女性。平均年龄为32.5岁(范围5 - 77)。n -甲基- d受体自身抗体结果(n = 14人,48%)、负(n = 7, 24%),富亮氨酸glioma-inactivated 1 (n = 6 21%),和contactin-associated蛋白质像2 (n = 1, 3%)。从发病到问卷收集的平均时间为6.3年(范围1.5 - -23.0)。10例(37%)出现抑郁的症状以PHQ9, 6(60%)报告严重的症状。PHQ9得分中位数为3(范围0-18)。 Six patients (22%) were experiencing symptoms of anxiety on the GAD7, with one (17%) reporting moderate-to-severe symptoms. Median GAD7 score was 2 (range 0-10). Eight patients (28%) reported a psychiatric history prior to the onset of AE, which was associated with increased PHQ9 scores (p = 0.04, Wilcoxon rank sum test).Conclusions The prevalence of self-reported depressive and anxious symptoms in this cohort in remission from AE was similar to general populations. Patients with a psychiatric history that preceded onset of AE had higher PHQ9 scores. These results may be affected by censoring bias and lower sensitivity of self-reported diagnostic tools.

map