PT -期刊文章盟Ramy Gabarin AU -朱利安赫伯特盟Seth Climans AU -亚历山德拉Muccilli李盟盟-悉尼-格雷戈里天盟理查德Wennberg盟——大卫Tang-Wai TI -自身免疫性脑炎的长期精神病症状缓解援助- 10.1212/01. wnl.0000903408.52359.84 DP - 2022年12月05 TA -神经病学PG - S50 S50 VI - 99 IP - 23补充2 4099 - //www.ez-admanager.com/content/99/23_Supplement_2/S50.1.short 4100 - http://n.neurolog首页y.org/content/99/23_Supplement_2/S50.1.full所以Neurology2022 12月05;99 AB -目标识别自我抑郁和焦虑症状的患病率在缓解患者自身免疫性脑炎(AE)。背景虽然之前研究发现高患病率的残余认知障碍患者在缓解AE,有一个缺乏这类患者长期精神结果数据。在正常人群,中位数病人健康Questionaire-9 (PHQ9)和一般焦虑Disorder-7 (GAD7)分数据报道,分别为3和2左右,与抑郁和焦虑症状的患病率在这些问卷调查报告为24%和23%左右。设计/方法回顾性横断面队列研究在三级中心AE诊所在2012-01-01和2012-01-01之间。患者通过电话联系或定期随访和PHQ9和GAD7完成。结果41例患者联系;29(71%)和包括回应。17(59%)是女性。平均年龄为32.5岁(范围5 - 77)。n -甲基- d受体自身抗体结果(n = 14人,48%)、负(n = 7, 24%),富亮氨酸glioma-inactivated 1 (n = 6 21%),和contactin-associated蛋白质像2 (n = 1, 3%)。从发病到问卷收集的平均时间为6.3年(范围1.5 - -23.0)。 Ten patients (37%) were experiencing symptoms of depression as measured by the PHQ9, with six (60%) reporting moderate-to-severe symptoms. Median PHQ9 score was 3 (range 0-18). Six patients (22%) were experiencing symptoms of anxiety on the GAD7, with one (17%) reporting moderate-to-severe symptoms. Median GAD7 score was 2 (range 0-10). Eight patients (28%) reported a psychiatric history prior to the onset of AE, which was associated with increased PHQ9 scores (p = 0.04, Wilcoxon rank sum test).Conclusions The prevalence of self-reported depressive and anxious symptoms in this cohort in remission from AE was similar to general populations. Patients with a psychiatric history that preceded onset of AE had higher PHQ9 scores. These results may be affected by censoring bias and lower sensitivity of self-reported diagnostic tools.

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