RT期刊文章SR电子T1氨甲环酸动脉瘤性蛛网膜下腔出血后摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e2605 OP e2614 10.1212 /首页 WNL。99签证官0000000000201160是23 A1莫德a Tjerkstra A1 Rene后A1 Menno r .德国A1默文是否Vergouwen A1 Korne Jellema A1内梅亨W . Koot A1 Nyika d Kruyt A1彼得西澳Willems A1碧玉f.c狼A1熔化c . de啤酒A1汉斯Kieft A1 Dharmin南达A1 Bram Gerwin后撤A1弗兰克·德·范德堡尔A1啤酒A1 Patricia H.A. Halkes A1卫矛j Reichman A1保罗J.A.M.这A1 Renske m . van den Berg-Vos A1文森特I.H.克瓦语A1 Taco c . van der Ree A1艾琳布朗A1亨利·p·Bienfait A1波Boogaarts A1 Catharina J.M. Klijn A1 Rene van den Berg A1伯特a指A1詹妮克角A1查尔斯B.L.M. Majoie A1 Gabriel J.E. Rinkel A1 Yvo B.W.M.鲁斯A1 W。彼得Vandertop A1达格玛Verbaan A1代表超调查者年2022 UL //www.ez-admanager.com/content/99/23/e2605.abstract 首页AB背景和目标超试验表明,ultra-early和短期氨甲环酸治疗蛛网膜下腔出血后没有改善临床结果在6个月。包括患者的比例预计nonaneurysmal蛛网膜下腔出血。在这篇文章的研究中,我们将调查是否ultra-early和短期氨甲环酸治疗动脉瘤性蛛网膜下腔出血患者在6个月改善临床结果。超试验方法是一个多中心、前瞻性、随机、对照、开放性试验盲法评估结果,7月24日之间进行的,2013年和2020年1月20日。蛛网膜下腔出血41 CT证实后,病人被分配到要么ultra-early和短期氨甲环酸治疗与常规治疗或常规治疗。在这篇文章的分析,我们包括所有超参与者证实动脉瘤在CT血管造影和/或数字减影血管造影。主要终点是在6个月的临床结果,评估改良Rankin规模(夫人),一分为二成一个优秀(0 - 3)和(4 - 6)的结果。813年超试验的结果经历了动脉瘤性蛛网膜下腔出血的患者,409例(50%)被分配到氨甲环酸组,404例(50%),对照组。意向处理分析,233年,405名(58%)患者238年氨甲环酸组和对照组的399名(60%)患者有很好的临床结果(调整优势比(aOR) 0.92; 95% CI 0.69–1.24). None of the secondary outcomes showed significant differences between the treatment groups: excellent clinical outcome (mRS 0–2) (aOR 0.76; 95% CI 0.57–1.03), all-cause mortality at 30 days (aOR 0.91; 95% CI 0.65–1.28), and all-cause mortality at 6 months (aOR 1.10; 95% CI 0.80–1.52).Discussion Ultra-early and short-term tranexamic acid treatment did not improve clinical outcomes at 6 months in patients with aneurysmal subarachnoid hemorrhage and therefore cannot be recommended.Trial Registration Information ClinicalTrials.gov (NCT02684812; submission date February 18, 2016, first patient enrollment on July 24, 2013).Classification of Evidence This study provides Class II evidence that tranexamic acid does not improve outcomes in patients presenting with aneurysmal subarachnoid hemorrhage.IQR=interquartile range; mRS=modified Rankin scale; mRS=odds ratio

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