% 0期刊文章% Nicola Jaime Adderley % % Anuradhaa Subramanian一个玛丽铂金% Krishnarajah Nirantharakumar %一个苏珊·p·Mollan %亚历山德拉•吉恩·辛克莱% T头痛、麻醉剂使用,处方趋势的女性特发性颅内高血压% B匹配以人群为基础的队列研究% D R 10.1212 / WNL 2022%。0000000000201064 % J首页神经病学% P e1968-e1978 % V 99% N 18% X背景和目标医生处方习惯鸦片和头痛疗法之前尚未评估在一个大的,匹配的队列研究特发性颅内高血压(IIH)。我们的目标是评估鸦片和头痛药物处方习惯与匹配的女性相比,颅内高压症女性偏头痛和人口控制。我们也调查了新发作的头痛的发生颅内高压症与人口控制。我们进行以人群为基础的匹配方法,回顾性队列研究来探索头痛的结果。横断面分析用来描述药物处方模式。我们使用数据从IQVIA医学研究数据,一个匿名,全国代表性初级护理电子病历数据库在英国,从1995年1月1日至2019年9月25日。16岁以上的女性都有资格列入。女性颅内高压症(暴露),年龄和身体质量指数与10控制女性没有颅内高压症但偏头痛(偏头痛控制),和没有颅内高压症或偏头痛(人口控制)。结果共有3411名妇女与颅内高压症13966偏头痛控制,和33495人口控制是包括在内。新出现的调整风险比头痛在颅内高压症与人口控制为3.09 (95% CI 2.78 - -3.43)。在确诊后的第一年,58%的女性与颅内高压症规定托吡酯乙酰唑胺和20%。 In total, 20% of women with IIH were prescribed opiates within the first year of their diagnosis, reducing to 17% after 6 years, compared with 8% and 11% among those with migraine, respectively. Twice as many women with IIH were prescribed opiates compared with migraine controls, and 3 times as many women with IIH were prescribed opiates compared with population controls. Women with IIH were also prescribed more headache preventative medications compared with migraine controls.Discussion Women with IIH were more likely to be prescribed opiate and simple analgesics compared with both migraine and population controls. Women with IIH trialed more preventative medications over their disease course suggesting that headaches in IIH may be more refractory to treatment.BMI=body mass index; CGRP=calcitonin gene-related peptide; IIH=idiopathic intracranial hypertension; IMRD=IQVIA Medical Research Data; THIN=The Health Improvement Network %U //www.ez-admanager.com/content/neurology/99/18/e1968.full.pdf