RT期刊文章SR电子T1APOE和脑小血管疾病标记脑出血患者摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯SP e1290 OP e1298 10.1212 / WNL。首页99签证官0000000000200851是12 A1伊莎贝尔夏洛特Hostettler A1大卫Seiffge A1安德鲁Wong A1 Gareth Ambler A1邓肯威尔逊A1克莱尔Shakeshaft A1 Gargi Banerjee A1 Nikhil Sharma A1汉斯Rolf Jager A1汉娜·科恩A1 Tarek a Yousry A1 Rustam Al-Shahi萨尔曼A1 Gregory Y.H.唇A1马丁·m·布朗A1基斯缪尔A1亨利Houlden A1 David j .回答年2022 UL //www.ez-admanager.com/content/99/12/e1290.abstract AB背景和目标我们调查APOE基因型之间的关联,脑出血(我)和神经影像学标记的脑淀粉样血管病(CAA首页)。方法包括患者前瞻性多中心英国观察性队列研究的患者我和代表英国人控制。首先,我们评估了协会的APOE基因型与我(相对于控件没有我)。其次,在我的患者中,我们评估了协会的APOE基因位点与血肿位置(大叶性或深)和脑CT创新艺人经纪公司的标志(卫星传回的预测(FLP)和蛛网膜下腔扩展(SAE))。结果我们包括907我患者和2636名对照。平均年龄为73.2岁(12.4 SD)年我例vs 69.6 (0.2 SD)人口控制;50.3%的病例和42.1%的控制是女性。与控制相比,任何APOEε2等位基因与我(大叶性和nonlobar)和叶的我自己占主导地位的模型(或1.38,95%可信区间1.13 - -1.7,p = 0.002或1.50,95%可信区间1.1 - -2.04,p = 0.01),但不深我的年龄调整分析(或1.26,95%可信区间0.97 - -1.63,p = 0.08)。作如下分析,APOEε4等位基因与大叶性与深我的年龄调整分析(或1.56,95%可信区间1.1 - -2.2,p = 0.01)。当评估创新艺人经纪公司标记,FLP APOE等位基因分别与有关(ε4:或者1.74,95%可信区间1.04 - -2.93,p = 0.04和ε2 /ε4:2.56,95% CI 0.99 - -6.61, p = 0.05)。我们没有找到APOE等位基因之间的关联和SAE。Discussion We confirmed associations between APOE alleles and ICH including lobar ICH. Our analysis shows selective associations between APOE ε2 and ε4 alleles with FLP, a CT marker of CAA. Our findings suggest that different APOE alleles might have diverging influences on individual neuroimaging biomarkers of CAA-associated ICH.CAA=cerebral amyloid angiopathy; CROMIS-2=Clinical Relevance of Microbleeds in Stroke; cSS=cortical superficial siderosis; FLP=finger-like projections; ICH=intracerebral hemorrhage; MRC NSHD=Medical Research Council National Survey of Health and Development; SAE=subarachnoid extension; SVD=small vessel disease