RT期刊文章SR电子T1β-Amyloid和τ成像在慢性创伤性脑损伤摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e1131 OP e1141 10.121首页2 / WNL。99签证官0000000000200857 11 A1阿米莉亚·j·希克斯A1珍妮l . Ponsford A1革顺施皮茨A1文森特·多尔A1娜塔莎Krishnadas A1卡罗琳·罗伯茨A1克里斯托弗·c·罗年2022 UL //www.ez-admanager.com/content/99/11/e1131.abstract AB背景和目标的创伤性脑损伤(TBI)被提升首页为阿尔茨海默病(AD)的危险因素。有证据表明β-amyloid升高(Aβ)和τ,广告的病理特点,创伤性脑损伤后立即。目前尚不清楚Aβ慢性时期和τ居高不下。为了解决这个问题,我们评估Aβ和τ负担长期创伤性脑损伤的幸存者和健康对照组使用PET成像。方法采用横断面设计,我们招募了个人一个中度到重度创伤性脑损伤后至少10年以前从住院病人的康复计划。类似的人口健康对照组从社区招募。宠物数据获得使用18 f-nav4694 (Aβ)和18 f-mk6240(τ)示踪剂。使用Centiloid规模Aβ沉积是量化。τ沉积是量化使用标准摄入值比率(SUVR) 4感兴趣的区域(roi)。 As a secondary measure, PET scans were also visually read as positive or negative. We examined PET data in relation to time since injury and age at injury. PET data were analyzed in a series of regression analyses.Results The sample comprised 87 individuals with TBI (71.3% male; 28.7% female; mean 57.53 years, SD 11.53) and 59 controls (59.3% male; 40.7% female; mean 60.34 years, SD 11.97). Individuals with TBI did not have significantly higher 18F-NAV4694 Centiloid values (p = 0.067) or 18F-MK6240 tau SUVRs in any ROI (p ≤ 0.001; SUVR greater for controls). Visual assessment was consistent with the quantification; individuals with TBI were not more likely than controls to have a positive Aβ (p = 0.505) or tau scan (p = 0.221). No associations were identified for Aβ or tau burden with time since injury (p = 0.057 to 0.332) or age at injury.Discussion A single moderate to severe TBI was not associated with higher burden of Aβ or tau pathologies in the chronic period relative to healthy controls. Aβ and tau burden did not show a significant increase with years since injury, and burden did not appear to be greater for those who were older at the time of injury.Aβ=β-amyloid; AD=Alzheimer disease; CapAIBL=Computational Analysis of PET from AIBL; Me=mesial temporal; OR=odds ratio; PTA=posttraumatic amnesia; ROI=region of interest; SUVR=standardized uptake value ratio; TBI=traumatic brain injury; Te=temporoparietal

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