RT期刊文章SR电子磁共振T1纵向变化形态测量学和组成与包涵体肌炎摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e865 OP e876 10.1212 / WNL。首页99签证官0000000000200776是9 A1迪迪埃·劳伦A1乔恩·里克•A1克里斯托弗·辛克莱D.J. A1 Parul休斯顿A1 Ronenn Roubenoff A1 Dimitris a .子宫颈A1阿提拉Nagy A1史蒂夫·派普A1 Tarek a Yousry A1迈克尔·g·汉娜A1 John s . Thornton A1佩德罗·m·马查多年2022 UL //www.ez-admanager.com/content/99/9/e865.abstract AB背景和目标有限的数据表明,定量核磁共振(qMRI)措施有可能被用作审判结果措首页施零星的包涵体肌炎(sIBM)和作为非侵入性评估工具研究sIBM肌肉病理过程。我们的目的是评估肌肉结构和成分的变化使用一个全面的多参数组qMRI措施和评价建构效度和响应性qMRI措施sIBM。这是一个前瞻性队列研究方法与评估基线(n = 30)和1年(n = 26)。qMRI评估包括大腿肌肉体积(TMV),国米/肌内脂肪组织(IMAT),肌肉脂肪分数(FF),肌肉炎症(T2弛豫时间),从T2 * IMAT放松(T2 * -IMAT),肌间的结缔组织从T2 *放松(T2 * -IMCT),和肌肉大分子结构的磁化传递率(地铁)。物理性能评估包括sIBM物理功能评估(sIFA), 6分钟步行距离,和定量的股四头肌肌肉测试。使用斯皮尔曼相关系数相关性进行评估。响应性是评估使用标准化的响应意味着(SRM)。结果1年之后,我们观察到的减少烟草花叶病毒(6.8%,p < 0.001)和肌肉T2 (6.7%, p = 0.035),增加IMAT (9.7%, p < 0.001), FF (11.2%, p = 0.030),结缔组织(22%,p = 0.995),和T2 * -IMAT (24%, p < 0.001),改变肌肉大分子结构(ΔMTR =−26%, p = 0.002)。减少肌肉T2与T2 * -IMAT增加相关(r =−0.47, p = 0.008)。沉积的结缔组织和sIFA IMAT与恶化(r = 0.38, p = 0.032; r = 0.34, p = 0.048; respectively), whereas a decrease in TMV correlated with a decrease in quantitative muscle testing (r = 0.36, p = 0.035). The most responsive qMRI measures were T2*-IMAT (SRM = 1.50), TMV (SRM = −1.23), IMAT (SRM = 1.20), MTR (SRM = −0.83), and T2 relaxation time (SRM = −0.65).Discussion Progressive deterioration in muscle quality measured by qMRI is associated with a decline in physical performance. Inflammation may play a role in triggering fat infiltration into muscle. qMRI provides valid and responsive measures that might prove valuable in sIBM experimental trials and assessment of muscle pathologic processes.Classification of Evidence This study provides Class I evidence that qMRI outcome measures are associated with physical performance measures in patients with sIBM.2D=2 dimensional; 3D=3 dimensional; 6MWD=6-minute walking distance; ActRII=activin type II receptor; BFL=biceps femoris long head; CV=coefficient of variation; FF=fat fraction; FOV=field of view; GRA=gracilis; IMAT=inter/intramuscular adipose tissue; MTC=magnetization transfer contrast; MTR=magnetization transfer ratio; qMRI=quantitative MRI; QMT=quantitative muscle testing; SAR=sartorius; SCAT=subcutaneous adipose tissue; sIBM=sporadic inclusion body myositis; sIFA=sIBM Physical Functioning Assessment; SM=semimembranosus; SPGR=spoiled gradient recalled echo; SRM=standardized response mean; ST=semitendinosus; T2*-IMAT=IMAT from T2* relaxation; T2*-IMCT=intermuscular connective tissue from T2* relaxation; TE=echo time; TFL=tensor fascia latae; TMV=thigh muscle volume; TR=repetition time; VLI=vastus lateralis and intermedius; VM=vastus medialis

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