RT期刊文章SR电子T1 Novelty-Related fMRI楔前叶和内侧颞区域的反应个体阿尔茨海默病的风险摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e775 OP e788 10.1212 / WNL。首页99签证官0000000000200667 A1是8欧v Billette A1加布里埃尔·齐格勒A1 Merita Aruci A1 Hartmut Schutze A1茉莉花m . Kizilirmak A1安妮Richter A1 Slawek Altenstein A1克劳迪娅巴特尔A1 Frederic Brosseron A1 Arturo Cardenas-Blanco A1菲利普Dahmen A1彼得Dechent A1劳拉Dobisch A1克劳斯Fliessbach A1 Silka黎明Freiesleben A1文策尔Glanz A1多琳GoerßA1约翰迪伦海恩斯A1 Michael t . Heneka A1 Ingo Kilimann A1 Okka Kimmich A1卢卡Kleineidam A1 Christoph Laske A1 Andrea Lohse A1 Ayda Rostamzadeh A1卡洛琳Metzger A1马提亚·h·蒙克A1奥利弗·彼得斯A1卢卡斯价格A1约瑟夫造粒机A1克劳斯Scheffler A1安雅施耐德A1安妮卡Spottke A1艾克Jakob Spruth A1阿尔弗雷多·拉米雷斯A1桑德拉Roske A1尼娜罗伊A1 Stefan Teipel A1迈克尔·瓦格纳A1 Jens Wiltfang A1 Steffen Wolfsgruber A1 Renat Yakupov A1彼得Zeidman A1 A1比约恩·h·弗兰克·安杰森Schott A1 Emrah Duzel A1安妮马斯河A1代表DELCODE研究小组2022年UL //www.ez-admanager.com/content/99/8/e775.abstract AB背景和目标我们评估是否novelty-related fMRI内侧颞叶区域的活动和楔前叶遵循一个倒u形的模式在提高阿尔茨海默病(AD)的临床表现正如前面建议的风险。首页具体来说,我们检测潜在的活动增加与更高的广告风险由于个人主观认知能力下降(SCD)或轻度认知障碍(MCI)。我们进一步测试是否活动差异诊断相关组占广告或脑萎缩的CSF标记。方法我们研究60 - 88岁的499名参与者从德国神经退行性疾病纵向认知障碍和老年痴呆症研究中心(DELCODE)接受了task-fMRI。参与者包括163认知正常(健康控制、HC)人,222年SCD, 82 MCI, 32临床诊断轻度AD患者。CSF水平β-amyloid 42/40比率和phosphorylated-tau181从232名参与者。我们提出分析用于评估novelty-related活动(小说>非常熟悉的场景)内嗅皮层、海马,楔前叶以及整个大脑voxel-wise分析。首先,一般线性模型测试fMRI活动参与者组之间的差异。互补的回归模型进行二次记忆障碍和活动之间的关系。 Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education.Results In the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the precuneus, hippocampal activity was reduced in AD dementia compared with all other groups and related to AD biomarkers.Discussion Novelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.AD=Alzheimer disease; AIC=Akaike information criterion; ANOVA=analysis of variance; CERAD=Consortium to Establish a Registry of AD; DMN=default mode network; FWE=family-wise error; FWHM=full width at half maximum; GLM=general linear model; GM=gray matter; HC=healthy control; MANCOVA=multivariate analysis of covariance; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; MNI=Montreal Neurological Institute; MTL=medial temporal lobe; ROI=region of interest; SCD=subjective cognitive decline; SPM=statistical parametric mapping; VBM=voxel-based morphometry