% 0期刊文章%一个塞西莉亚·凯利%卡Parra-Cantu % Prabin Thapa %一个伯纳德j·斯莱姆博因顿布拉德利% %一个埃里克·j·索伦森%詹妮弗·m . Martinez-Thompson % Jaywant Mandrekar % Nathan p .员工% T比较不同的呼吸测试的性能参数检测早期呼吸功能不全患者的肌萎缩性侧索硬化症% D R 10.1212 / WNL 2022%。0000000000200758 % J首页神经病学% P e743-e750 % V 99% N 7% X背景和目标比较不同呼吸功能测试的性能参数在一个多学科的肌萎缩性脊髓侧索硬化症(ALS)诊所。方法统计、临床数据和呼吸测试参数抽象从病人的医疗记录参加了一个多学科ALS诊所从2008年到2016年。我们比较3主呼吸测试的性能参数所使用的医疗保险的起始无创性通气(17)(用力肺活量(FVC) < 50%的预测,最大吸气压力(MIP) < 60厘米的水,一夜之间异常脉搏血氧仪[OvOx])如何相关的几个临床相关的属性。结果四百七十六例患者被确定接受至少1呼吸测试。OvOx异常、MIP和FVC发生在中值为1.6,1.5,和3.8年疾病发作,分别(p < 0.00001)。bulbar-onset ALS患者表现出异常MIP和FVC比早些时候在spinal-onset ALS (p < 0.005)。生存中值异常OvOx之后,MIP,或FVC测试为1.4,1.4,和0.9年(p < 0.0001)。使用ALS功能评级呼吸分量表得分,当时报道的呼吸道症状OvOx有异常(60%)、MIP(69%),和FVC (19%)。相反,当呼吸参数异常之前报道呼吸道症状,这发生在OvOx频率(79%)、MIP (42%)、FVC (24%)。四百四十三名患者(93.1%)开发至少1异常呼吸测量会议和合考虑医疗保险标准,但不到50%在我们组展示了和合使用。改善生存在受试者使用和合bulbar-onset ALS患者达到统计上的显著水平。讨论异常OvOx和MIP执行比FVC在肌萎缩性侧索硬化症早期发现神经肌肉呼吸系统的弱点。 Initiation of NIV in patients with respiratory insufficiency may improve the overall survival in ALS. In the setting of the COVID-19 pandemic, FVC and MIP have not been routinely performed because of infectious aerosol generation. OvOx, which we now routinely mail to patients' homes, has been used exclusively during the COVID-19 pandemic and allows for continued remote monitoring of the respiratory status of patients with ALS.Classification of Evidence This cohort study provides Class III evidence that in people with ALS, OvOx and MIP are valuable respiratory parameters for the detection of early respiratory insufficiency.ALS=amyotrophic lateral sclerosis; ALSFRS-R=Revised Amyotrophic Lateral Sclerosis Functional Rating Scale; FVC=forced vital capacity; MIP=maximum inspiratory pressure; NIV=noninvasive ventilation; OvOx=overnight pulse oximetry; SaO2=oxygen saturation %U //www.ez-admanager.com/content/neurology/99/7/e743.full.pdf