PT -期刊文章盟应商盟Linnea韦德曼AU -汉斯·哈格斯特龙TI -非酒精性脂肪肝病和痴呆的风险- 10.1212 / WNL援助。0000000000200853 DP - 2022年8月09年TA -神经病首页学PG - e574 e582 VI - 99 IP - 6 4099 - //www.ez-admanager.com/content/99/6/e574.short 4100 - //www.ez-admanager.com/content/99/6/e574.full所以Neurology2022 09年8月;99 AB -背景和目标的非酒精性脂肪肝病(NAFLD)和老年痴呆症的共同危险因素包括代谢紊乱。然而,非酒精性脂肪肝是否与痴呆风险尚不清楚。我们调查了非酒精性脂肪肝和痴呆风险之间的联系以及心血管并发症的作用包括心脏病和中风。匹配以人群为基础的队列研究方法,我们发现所有瑞典患者65岁或以上的老人NAFLD确定国家病人登记(NPR)在1987年和2016年之间。这些是与10个人参考普通人群的年龄、性别、和直辖市的诊断。事件痴呆诊断来源于NPR或直到2016年死因登记。调整风险比率(明显)和95%独联体和Cox回归模型估计。结果共有2898例非酒精性脂肪肝患者和28357匹配控制被确定(平均年龄在条目,四分位范围(差),70 [8]; 55.1% female). During a median follow-up of 5.5 years (IQR: 8.5 years), 145 (5.0%) patients with NAFLD and 1,291 (4.6%) reference individuals were diagnosed with dementia. Compared with the reference individuals, patients with NAFLD had higher rates of dementia (aHR 1.38, 95% CI 1.10–1.72) and vascular dementia (aHR 1.44, 95% CI 0.96–2.23, p = 0.07). Comorbid NAFLD and either heart disease (aHR 1.50 95% 1.08–2.05) or stroke (aHR 2.60 95% CI 1.95–3.47) conferred a greater risk of dementia.Discussion NAFLD had a modest association with increased rates of dementia. This was stronger among patients with NAFLD diagnosed with cardiovascular comorbidities.Classification of Evidence This study provides Class II evidence that nonalcoholic fatty liver disease is associated with the development of vascular and nonvascular dementia.AD=Alzheimer disease; aHR=adjusted hazard ratios; CDR=cause of death register; CVD=cardiovascular diseases; HD=heart disease; HR=hazard ratio; ICD=International Classification of Disease; IQR=interquartile range; NAFLD=nonalcoholic fatty liver disease; NPR=National Patient Register; PPV=positive predictive value

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