PT -期刊文章盟Sunghye赵盟Katheryn亚历山德拉Quilico兄弟盟-神采Shellikeri盟沙龙灰非盟-大卫·约翰·欧文盟马克Yoffe Liberman AU -莫里格罗斯曼盟Naomi Nevler TI -词汇和声学语音特征与阿尔茨海默病病理援助- 10.1212 / WNL。0000000000200581 DP - 2022年7月26日TA -神经病首页学PG - e313 e322 VI - 99 IP - 4 4099 - //www.ez-admanager.com/content/99/4/e313.short 4100 - //www.ez-admanager.com/content/99/4/e313.full所以Neurology2022 7月26日;99 AB -背景和目标我们比较数字语音和语言特征的患者遗忘阿尔茨海默病(aAD)或原发性进行性失语logopenic变体(lvPPA)生物确认队列和相关神经精神考试分数和CSF分析物这些特性。方法包括广告或lvPPA患者CSF(磷酸化τ([p-tau] /β-amyloid Aβ≥0.09,和总τ/ Aβ≥0.34)或解剖确认广告病理学和年龄健康对照组(HC)额颞叶退化中心招募了宾夕法尼亚大学的横断面研究。我们提取的演讲和语言变量与自动词汇和声学管道从参与者的口头描述图片。我们将组织和关联不同的特性与临床评分和CSF p-tau水平。结果我们检查患者aAD (n = 44;62±8岁;24岁女性;细微精神状态检查(MMSE)得分21.1±4.8)或lvPPA (n = 21;64.1±8.2岁;11个女人; MMSE score 23.0 ± 4.2) and HC (n = 28; age 65.9 ± 5.9 years, 15 women; MMSE score 29 ± 1). Patients with lvPPA produced fewer verbs (10.5 ± 2.3; p = 0.001) and adjectives (2.7 ± 1.3, p = 0.019) and more fillers (7.4 ± 3.9; p = 0.022) with lower lexical diversity (0.84 ± 0.1; p = 0.05) and higher pause rate (54.2 ± 19.2; p = 0.015) than individuals with aAD (verbs 12.5 ± 2; adjectives 3.8 ± 2; fillers 4.9 ± 4.5; lexical diversity 0.87 ± 0.1; pause rate 45.3 ± 12.8). Both groups showed some shared language impairments compared with HC. Word frequency (MMSE score: β = −1.6, p = 0.009; Boston Naming Test [BNT] score: β = −4.36, p < 0.001), adverbs (MMSE score: β = −1.9, p = 0.003; BNT score: β = −2.41, p = 0.041), pause rate (MMSE score: β = −1.21, p = 0.041; BNT score: β = −2.09, p = 0.041), and word length (MMSE score: β = 1.75, p = 0.001; BNT score: β = 2.94, p = 0.003) were significantly correlated with both MMSE and BNT scores, but other measures were not correlated with MMSE and/or BNT score. Prepositions (r = −0.36, p = 0.019), nouns (r = −0.31, p = 0.047), speech segment duration (r = −0.33, p = 0.032), word frequency (r = 0.33, p = 0.036), and pause rate (r = 0.34, p = 0.026) were correlated with patients' CSF p-tau levels.Discussion Our measures captured language and speech differences between the 2 phenotypes that traditional language-based clinical assessments failed to identify. This work demonstrates the potential of natural speech in reflecting underlying variants with AD pathology.aAD=amnestic AD; Aβ=β-amyloid42; AD=Alzheimer disease; BNT=Boston Naming Test; lvPPA=logopenic variant PPA; p-tau=phosphorylated tau; POS=part-of-speech; PPA=primary progressive aphasia

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