TY - T1的住院的结果和复发的急性缺血性中风患者的器官恶性肿瘤JF -神经学乔-神经病学SP - e393 LP - e401做- 10.1212 / WNL。首页0000000000200601六世- 99 - 4盟Aayushi加戈盟Saurav Chopra AU -马修·斯塔尔AU -马塞洛•罗查AU -朱迪Dawod AU -恩里克Leira盟Amir Shaban Y1 - 2022/07/26 UR - //www.ez-admanager.com/content/99/4/e393.abstract N2 -背景和目标这首页项工作的目的是评估的影响器官恶性肿瘤住院的结果和复发性中风患者住院急性缺血性中风(AIS)。成人住院治疗AIS的主要诊断方法确定了从2016年到2018年从全国范围内再入院数据库。逻辑回归是用来比较的差异使用急性中风患者的干预和临床结果和没有恶性肿瘤。生存分析是用来评估的风险重新接纳放电后由于中风复发。结果有1385840人住院由于AIS(平均数±标准差为70.4±14.0岁,女性50.2%)。其中,50553例(3.7%)并发器官恶性肿瘤的诊断。5最常见恶性肿瘤包括肺癌(24.6%)、前列腺癌(13.2%)、乳腺癌(9.3%),胰腺癌(6.5%)和结肠直肠癌(6.2%)。调整基线差异后,恶性肿瘤患者更可能intraparenchymal出血(比值比(或)1.11,95% CI 1.04 - -1.19),住院死亡率(或2.15,95%可信区间2.04 - -2.28),和放电处理除了家里(或1.70,95%可信区间1.64 - -1.75)。恶性肿瘤患者不太可能接受静脉溶栓(组织纤溶酶原激活物(tPA))和更有可能接受机械血栓切除术(MT)。子组中患者tPA或太,结果是没有恶性肿瘤患者之间的可比性,除了肺癌患者的风险保持在一个更高的死亡率和不良性格,尽管这些急性中风干预措施。 Patients with malignancy were at a higher risk of readmission due to recurrent AIS within 1 year of discharge (hazards ratio 1.18, 95% CI 1.11–1.25), and this risk was driven specifically by the lung and pancreatic cancers.Discussion While patients with malignancy generally have worse in-hospital outcomes compared to those without, there is considerable variation in these outcomes according to the different cancer types and the use of acute stroke interventions. The use of tPA and MT is generally safe for eligible patients with an underlying malignancy. Patients with lung and pancreatic cancers have a higher early risk of recurrent stroke and might need more intensive surveillance and careful institution of the optimal secondary prevention measures.AIS=acute ischemic stroke; aOR=adjusted odds ratio; HR=hazards ratio; ICD-10=International Statistical Classification of Diseases and Related Health Problems, 10th revision; IPH=intraparenchymal hemorrhage; MT=mechanical thrombectomy; NRD=Nationwide Readmissions Database; SAH=subarachnoid hemorrhage; SASI=Stroke Administrative Severity Index; tPA=tissue plasminogen activator ER -