% 0期刊文章%艾德丽安锡% % 1月布雷斯勒一个珍妮特Simino %一个凯文·j·沙利文%郝美% b格温温德姆%迈克尔·格里斯沃尔德%的丽贝卡·f·戈特斯曼% Eric Boerwinkle %一个托马斯·h·莫斯利Myriam Fornage % % T遗传风险,中年生活简单的7,在动脉粥样硬化和事件痴呆风险在社区研究中% D R 10.1212 / WNL 2022%。0000000000200520 % J首页神经病学% P e154-e163 % V 99% N 2% X背景和目标更高的分数在生活简单的7 (LS7)、心血管和大脑健康的指标,降低患上痴呆的风险。目前不能确定协会持有那些高遗传风险的痴呆。我们的目标是评估的程度,LS7可能抵消痴呆风险遗传风险的范围。方法在社区参与动脉粥样硬化的风险(ARIC)研究从1987 - 1989年到2019年。我们推导出中年LS7分数和生成遗传风险得分(GRS)使用全基因组阿尔茨海默病的汇总统计,已被用于研究基因患老年痴呆症的风险。事件痴呆的确定是基于标准研究所Aging-Alzheimer协会工作组和精神疾病诊断与统计手册。GRS LS7与事件的关联痴呆使用Cox回归进行评估。结果本研究包括8823名欧洲美国(EA)和2738名非裔美国人(AA)参与者在基线(平均年龄54年)。我们观察1603例老年痴呆症在EA参与者和631 AA参与者(平均随访26.2年)。更高GRS与痴呆的风险更高(EA,风险比[HR] / SD 1.44, 95% CI 1.37, 1.51; AA, HR 1.26, 95% CI 1.16, 1.36). Among EA participants, higher LS7 scores were consistently associated with lower risk of dementia across quintiles of GRS, including the highest quintile (HR per point 0.91, 95% CI 0.87, 0.96). Among AA participants, the associations between LS7 and incident dementia within stratum of GRS had the same direction as among EA participants, although wide CIs and smaller sample sizes limited reliable inferences.Discussion Across strata of GRS, higher midlife LS7 scores were associated with lower risk of dementia. Larger sample sizes from diverse populations are needed to obtain more reliable estimates of the effects of modifiable health factors on dementia risk within genetic risk strata in each ancestry group.AA=African American; AD=Alzheimer disease; AHA=American Heart Association; ARIC=Atherosclerosis Risk in Communities; BioLINCC=Biologic Specimen and Data Repository Information Coordinating Center; CVD=cardiovascular disease; DSM-5=Diagnostic and Statistical Manual of Mental Disorders, 5th Edition; EA=European American; FINGER=Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability; GRS=genetic risk scores; GWAS=genome-wide association studies; HR=hazard ratio; ICD-9=International Classification of Diseases–9; LS7=Life's Simple 7; PC=principal component; SBP=systolic blood pressure; SNP=single nucleotide polymorphism; TICS=Telephone Interview for Cognitive Status %U //www.ez-admanager.com/content/neurology/99/2/e154.full.pdf