RT期刊文章SR电子T1冲动性特质小脑性共济失调患者资料和帕金森病摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e176 OP e186 10.1212 / WNL。首页99签证官0000000000200349 x 2 A1蒂芙尼陈A1 Chi-Ying r .林A1梅根·a . Aumann A1欣欣A1 Nadia Amokrane A1娜塔莎a德赛A1 Hakmook Kang A1丹尼尔·o·Claassen A1 Sheng-Han郭年2022 UL //www.ez-admanager.com/content/99/2/e176.abstract AB背景和目标患者小首页脑性共济失调(CA)可以开发冲动行为症状,往往导致对人际关系造成负面影响,不利地影响他们的生活质量。有限的证据对CA及其相关的冲动行为变化。我们评估冲动特质在CA使用Barratt冲动性量表(BIS-11)和帕金森病(PD)的比较调查的差异之间的脉冲特征资料CA和PD。方法:我们进行了一次dual-center横断面研究和CA患者PD登记通过连续抽样运动障碍诊所哥伦比亚大学医学中心和范德比尔特大学医学中心,分别。年龄组在各自的机构被吸收了。参与者排除如果他们之前或共病神经和精神疾病与冲动。所有参与者完成了BIS-11问卷测量的脉冲特征。我们使用一般线性回归模型和最小绝对收缩和选择操作比较,次生氧化皮,个别项目之间的BIS-11分数组。子群分析孤立小脑贡献冲动extracerebellar病理学和多巴胺功能障碍或潜在影响的药物。结果共有190名参与者- 90年龄组,50参与者与CA, 50 PD-completed评估。 Persons with CA reported 9.7% higher BIS-11 scores than controls (p < 0.001), while persons with PD reported 24.9% higher scores than controls (p < 0.001). In CA, the most affected domain of impulsivity was nonplanning. In contrast, persons with PD noted greater impulsivity across the nonplanning, attentional, and motor domains.Discussion Impulsivity in CA is uniquely driven by the nonplanning trait, unlike in PD. This suggests that the cerebellum and basal ganglia may differentially govern impulsive behaviors with the cerebellum contributing to the brain circuitry of impulsivity in a domain-specific manner.BIS-11=Barratt Impulsivity Scale; CA=cerebellar ataxia; CCAS=cerebellar cognitive affective syndrome; FA=Friedrich ataxia; FDR=false discovery rate; GLM=generalized linear model; ILOCA=idiopathic late-onset CA; LASSO=least absolute shrinkage and selection operation; MSA-C=multiple system atrophy–cerebellar type; PD=Parkinson disease; SCA=spinocerebellar ataxia

map