TY - T1的白质绑定宠物:匹兹堡化合物b和Flutemetamol (p12 - 4.010) JF -神经学乔-神经学六世- 98 - 18补充SP - 2740 AU - Burcu Zeyd首页an AU -克里斯托弗·g·施瓦兹盟斯科特·a·Przybelski盟——蒂莫西·g·Lesnick盟——沃尔特·k·克雷默AU -马修·l·Senjem盟保罗h . Min AU -布拉德利·j·坎普盟克利福德·r·杰克,小非盟- Orhun h . Kantarci盟Kejal Kantarci AU - Val j·劳Y1 - 2022/05/03 UR - //www.ez-admanager.com/content/98/18_Supplement/2740.abstract N2 -目的:调查是否类似的白质的变化之间存在(WM)绑定C11-Pittsburgh化合物b(加以)和F18-Flutemetamol (FMT)宠物配体。背景:宠物与β-amyloid配体分子成像技术正成为针对WM完整性。加以似乎是一个敏感和可靠的宠物配体测量WM完整性,但是鉴于其半衰期短,这不是商用。F18配体如FMT有更长的半衰期可能是一个选择。设计/方法:认知没有(铜)年长和年轻成人志愿者应对研究的包括广告β-amyloid宠物(N = 61)。个人预期接受了核磁共振,加以和FMT宠物。MRI-FLAIR图像划分为WM hyperintensity(负责人)和正常WM (NAWM)和注册t1加权图像。加以和FMT宠物图像注册t1加权图像。加以吸收和FMT标准价值比率(SUVrs)负责人和NAWM计算使用小脑小腿吸收作为参考。结果:平均年龄是67岁老年人(61 - 83年)和38年(30-48年)在年轻的成年人。加以和FMT SUVrs老相比年轻铜成人高负责人(术中,0.001)和NAWM(术中,0.001)。研究负责人和NAWM SUVrs与FMT是高于加以老(术中,0.001)和年轻的成年人(术中;0.001)铜。 PiB and FMT SUVrs were higher in NAWM compared to WMH in older (p<0.001) and younger (p<0.001) CU adults. There was no apparent difference between PiB versus FMT SUVrs in differentiating WMH from NAWM in older and younger adults.Conclusions: PiB and FMT can successfully distinguish between WMH and NAWM. In WMH and NAWM, PiB and FMT show a similar topographical pattern of uptake in WM with a similar age association. However, given its longer half-life, commercial availability, and higher binding potential, FMT can be an alternative to PiB in PET, specifically targeting MS.Disclosure: The institution of Dr. Zeydan has received research support from National Institutes of Health. The institution of Christopher Schwarz has received research support from NIH. Scott Przybelski has nothing to disclose. Timothy Lesnick has received personal compensation for serving as an employee of Mayo Clinic. The institution of Walter Kremers has received research support from Biogen. Matthew Senjem has received stock or an ownership interest from Align Technology, Inc.. Matthew Senjem has received stock or an ownership interest from Inovio Biomedical Corp.. Matthew Senjem has received stock or an ownership interest from Johnson & Johnson. Matthew Senjem has received stock or an ownership interest from Mesa Laboratories, Inc.. Matthew Senjem has received stock or an ownership interest from Nvidia Inc.. Matthew Senjem has received stock or an ownership interest from LHC Group, Inc.. Matthew Senjem has received stock or an ownership interest from Natus Medical Incorporated. Matthew Senjem has received stock or an ownership interest from Varex Imaging Corporation. Matthew Senjem has received personal compensation in the range of $100,000-$499,999 for serving as a IT Technical Specialist II with Mayo Clinic. Hoon-Ki Min has nothing to disclose. Brad Kemp has nothing to disclose. The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic. Dr. Kantarci has nothing to disclose. The institution of Dr. Kantarci has received research support from Eli Lilly. The institution of Dr. Kantarci has received research support from NIH. The institution of Dr. Kantarci has received research support from ADDF. Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals. ER -