TY - T1的终身Synucleinopathies便秘:一个事件队列研究奥姆斯特德县MN (1991 - 2010)。(p13 - 11.006) JF 首页-神经学乔-神经学六世- 98 - 18补充SP - 1713 AU -又是Turcano AU -埃Camerucci盟艾丹马伦AU -科尔刺伤盟Adil启动非盟- Delana Weis AU -布拉德利Boeve AU -詹姆斯·鲍尔AU - j . Eric Ahlskog盟Rodolfo Savica Y1 - 2022/05/03 UR - //www.ez-admanager.com/content/98/18_Supplement/1713.abstract N2 -目的:探讨便秘的终身协会α-Synucleinopathies时代相比,sex-matched控制。背景:便秘是一个很好的描述帕金森病(PD)的运动特性;然而,只有很少有研究探讨了终身的便秘帕金森病痴呆(PDD),与路易体痴呆(下文)和多系统萎缩(MSA)。设计/方法:我们使用了罗彻斯特流行病学项目(代表)之间建立一个事件群α-Synucleinopathies 1991 - 2010。运动障碍专家审查了所有临床医学图表确认诊断。继发性便秘原因被排除在外。每一个案件是搭配一个——和sex-matched控制时代。结果:在453例公开α-Synucleinopathies 303 PD, 80下文,54 PDD,和16 MSA。便秘出现在大约50%的所有α-Synucleinopathies (PD的50%,53%的下文,PDD的44%,和50%的MSA),一半的情况下有明显α-Synucleinopathies发作之前出现。在所有synucleinopathies,下文有最早的中值出现便秘pre-motor阶段(3.8年在症状出现之前,差= 1.7 - -5.9)。而在post-motor阶段,PD的最新值出现便秘(5.2年后症状发作,差= 2.7 - -8.0)。PD患者频率最高(18.2%)的长期便秘(发生在20年之前运动症状发作)。All patients later diagnosed with α-Synucleinopathies, except for MSA (p= 0.09), had higher odds of reporting constipation prior to the onset of motor symptoms as compared to controls.Conclusions: PD, DLB, and PDD had higher odds of having constipation before motor symptoms onset, as compared to controls. PD was most likely associated with longstanding constipation (>20 years before symptoms onset). Our results indicate that constipation rates (overall, pre-, and post-motor) do not differ among α-Synucleinopathies; however, temporal onset of constipation showed differences among α-Synucleinopathies, possibly due to differences in disease etiology and/or α-Synuclein spread.Disclosure: Dr. Turcano has nothing to disclose. Dr. Camerucci has nothing to disclose. Aidan Mullan has nothing to disclose. Mr. Stang has nothing to disclose. Delana Weis has nothing to disclose. Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Biogen. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from GE Healthcare. Dr. Boeve has received publishing royalties from a publication relating to health care. The institution of Dr. Bower has received research support from Abbvie. Dr. Ahlskog has received publishing royalties from a publication relating to health care. The institution of Dr. Savica has received research support from ACADIA Pharmaceuticals, Inc. ER -