TY - T1的与性有关的差异在上肢运动功能在健康受试者和多发性硬化症病人:Multiparamentric MRI研究(p1 - 1.虚拟)JF -神经学乔-神经学六世- 98 - 18补充SP - 1298 AU -奇亚拉Maspero Elisabetta帕加尼AU -拉斐尔Bonacchi盟盟,Paola Valsasina盟-亚首页历山德罗代表我非盟-玛丽亚·A·罗卡AU -马西莫菲利皮主持Y1 - 2022/05/03 UR - //www.ez-admanager.com/content/98/18_Supplement/1298.abstract N2 -目的:探索与性有关的上肢运动性能的差异(9洞桩测试[9 hpt])在健康对照组(HC)和多发性硬化症患者(pwm)和MRI基质。背景:与性有关的影响表现在越来越规范的测试调查,对个性化的护理,提高疾病病理生理学的知识。设计/方法:94 HC和133 pwm(右撇子)经历了9成政府和大脑3 t MRI序列区域灰质体积(GMV)白质(WM)分数各向异性(FA)和静止状态(RS)功能连通性(FC)分析。分布的关联分析MRI变量与9 hpt性能,我们构建了一个一般线性模型包括一组分类变量(female-HC、male-HC female-pwMS, male-pwMS), 9成z分数,和他们的相互作用。协会的MRI在每组变量与9 hpt调查;不同的关联进行了测试。结果:9成性能更好的HC vs pwm和女性与男性HC,类似在女性和男性pwm。在HC,更好的9成性能与高容量电动机和前运动皮质在两种性别中,女性比男性更强的正相关性。在pwm,更糟糕的是9成性能降低音量在电动机和前运动皮质,但与性有关的差异最小,主要发现在小脑地区。WM FA分析披露不联想到9 hpt HC的表现,也不与性有关的pwm的差异。RS FC分析显示:在感觉运动网络,加强协会与9 hpt性能在女性和男性在HC,虽然没有在pwm与性有关的差异; in the cerebellar network, no sex-related differences in HC but a stronger negative correlation in males vs females in left cerebellum in pwMS.Conclusions: Sex influences 9HPT performance in HC, mainly through differences in volume and RS FC of motor and premotor cortical areas. Sex-related effect becomes secondary in pwMS, and explicated through modifications in cerebellar areas.Disclosure: Mrs. Maspero has nothing to disclose. Raffaello Bonacchi has nothing to disclose. Elisabetta Pagani has nothing to disclose. Paola Valsasina has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ACCMED. Alessandro Meani has nothing to disclose. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Bristol Myers Squibb, Celgene, Genzyme, Merck Serono, Novartis, Roche, and Teva. The institution of Maria Assunta Rocca has received research support from Italian Ministry of Health, MS Society of Canada and Fondazione Italiana Sclerosi Multipla. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). ER -