TY - T1的早发性帕金森病的发病率趋势奥姆斯特德县。内格罗蓬特:1976 - 2013。(S12.003) JF -神首页经学乔-神经学六世- 98 - 18补充SP - 1614 AU -埃Camerucci AU -艾登·马伦盟又是Turcano AU -科尔刺伤盟Delana Weis AU -布拉德利Boeve AU -詹姆斯·鲍尔AU - j . Eric Ahlskog盟Rodolfo Savica Y1 - 2022/05/03 UR - //www.ez-admanager.com/content/98/18_Supplement/1614.abstract N2 -目的:确定38年发病率趋势和生存的早发性帕金森病(EOPD)在奥姆斯特德县,MN。背景:很少有研究调查EOPD发病率的趋势。设计/方法:我们使用了罗彻斯特流行病学项目定义以人群为基础的队列EOPD奥姆斯特德县从1976 - 2013 MN。运动障碍专家审查所有的临床记录确认PD的诊断。定义EOPD,我们使用两个截止年龄在50 - 55岁。结果:EOPD发病率为1.52/100000人年≤55集团截止时,0.60/100000的人每年≤50岁。男人比女人有更高的发病率在两个年龄组(1.98 vs 1.09;和0.70 vs 0.50)。EOPD诊断在55岁之前的发病率增加每十年:从person-year在1976 - 1985之间,0.99/100.000到1.71/100.000 person-year在2006 - 2013之间。类似的趋势在EOPD除以几十年的发病率组患者诊断≤50岁(0.26/100000人每年在1976 - 1985年0.82/100000 person-year在2006 - 2013年)。 Incidence was higher in men than women in each decade with the exception of 2006–2013 in the EOPD group diagnosed before the age of 50. Median time from EOPD symptom onset to death was not significantly different between sexes, for both EOPD ≤55 (21.0 years in men vs 22.1 years in women, p= 0.97) and EOPD ≤50 (20.4 in men vs 19.8 in women, p= 0.86).Conclusions: We observed an increase in the incidence of EOPD over a 40-year span; this may be secondary to better recognition by physicians and/or improved diagnostic tools but can be also caused by differences in environmental exposures and risk factors.Disclosure: Dr. Camerucci has nothing to disclose. Aidan Mullan has nothing to disclose. Dr. Turcano has nothing to disclose. Mr. Stang has nothing to disclose. Delana Weis has nothing to disclose. Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Biogen. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from GE Healthcare. Dr. Boeve has received publishing royalties from a publication relating to health care. The institution of Dr. Bower has received research support from Abbvie. Dr. Camerucci has nothing to disclose. The institution of Dr. Savica has received research support from ACADIA Pharmaceuticals, Inc. ER -