% 0期刊文章%又是一个Turcano % Emanuele Camerucci %艾丹马伦%一个科尔刺伤%一个布拉德利Boeve Delana Weis % %詹姆斯·鲍尔%一个Rodolfo Savica J . Eric Ahlskog % % T大脑首先与身体Synucleinopathies:以人群为基础的队列研究(p16 - 11.006) % D J神经病学2022% % P V 98% 1706% N % X 18补充目的:区分大脑和身体alpha-synucleinopathies和描述他们的临床特点。首页背景:大脑- vs身体假说提出了识别最初的α-突触核蛋白存款alpha-synucleinopathies聚合。设计/方法:我们使用了罗彻斯特流行病学项目(代表)建立以人群为基础的队列alpha-synucleinopathies奥姆斯特德县(MN) 1991 - 2005。运动障碍专家审查所有医学图表确认帕金森病(PD)的临床诊断,与路易体痴呆(下文)和帕金森病痴呆(PDD)。多系统萎缩(MSA)是不包括在本研究由于这个诊断患者的队列。至少2以下症状的存在之前的运动帮助我们定义身体出现症状组比大脑首先组没有他们:便秘、勃起功能障碍、REM睡眠行为障碍的嗅觉缺失症、神经性膀胱功能障碍。结果:大脑首先患者(n = 228)更有可能比身体PD患者(或= 2.51,p = 0.004),而身体(n = 50)的患者更有可能有下文(或= 5.19,p < 0.001)。PDD是不相关的群体(p = 0.09)。患者身体没有较高的地震(或= 0.55,p = 0.06),动作迟缓(或= 0.87,p = 0.84),和刚度(或= 0.92,p = 0.85)相比大脑首先组。同样的,没有风险的差异运动障碍(HR = 1.43, p = 0.28)和死亡的危险(HR = 0.89, p = 0.497)组。alpha-synucleinopathies,结论:在我们的人口基数的大脑首先患者更有可能出现PD病人身体相比,和身体的病人更有可能发展下文。无显著差异运动症状的风险以及发展运动障碍和死亡的风险被观察到在我们的团体之间的群体。披露:Turcano博士没有披露。 Dr. Camerucci has nothing to disclose. Aidan Mullan has nothing to disclose. Mr. Stang has nothing to disclose. Delana Weis has nothing to disclose. Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Biogen. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from GE Healthcare. Dr. Boeve has received publishing royalties from a publication relating to health care. The institution of Dr. Bower has received research support from Abbvie. Dr. Ahlskog has received publishing royalties from a publication relating to health care. The institution of Dr. Savica has received research support from ACADIA Pharmaceuticals, Inc. %U