RT期刊文章SR电子T1血浆神经丝光水平增加放射检查孤立综合症患者(p1 - 1. -虚拟)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 2084签证官98年18补充A1拉斐尔施耐德A1 Koroboshka Brand-Arzamendi A1 (Timo首页thy雷诺Lim A1杰弗里·格莱斯特A1梅勒妮Guenette A1 Suradech Suthiphosuwan A1 Aditya Bharatha A1 Jiwon哦年2022 UL //www.ez-admanager.com/content/98/18_Supplement/2084.abstract AB目的:评估的不同等离子体光神经丝(pNfL)放射检查孤立综合症患者(pwRIS)与健康对照组(高碳钢)和关联pNfL水平与先进的磁共振成像(MRI)在pwRIS标记。背景:RIS指的是那些没有典型的症状,但女士大脑病变MRI特点与女士(pwm)。疾病修饰治疗的早期启动(DMT)可以提高pwm的预后,但目前没有明确如何管理pwRIS以证据为基础的指导方针。我们曾表明,绝大多数的pwRIS显示高比例的白质病变(wml)展示中央静脉(CVS)标志。之前的研究表明,血液NfL水平pwm与MRI的措施。我们假设pNfL水平增加一些pwRIS和与先进的核磁共振的措施。设计/方法:14 RIS主题和6高碳钢接受3 t大脑和颈部脊髓磁共振成像和测量水平pNfL HD-1 Simoa平台(Quanterix)。学生的t;和Mann-Whitney U-tests被用来评估差异RIS和高碳钢。结果:pwRIS pNfL与高碳钢的水平较高(p < 0.05)。pwRIS超过20 CVS-positive病变或超过50个总wml pNfL水平明显高于与高碳钢。结论:本试验研究是第一个证明pNfL pwRIS水平增加,与CVS-positive病变的数量和wml的总数。 Although requiring prospective confirmation in a larger cohort, these findings suggest that pNfL may have prognostic value in identifying those pwRIS who are at high risk of developing MS. Prospective clinical validation is underway to confirm this hypothesis.Disclosure: Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol-Myers Squibb. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Mrs. Brand-Arzamendi has nothing to disclose. Timothy R. Lim has nothing to disclose. Dr. Glaister has nothing to disclose. Melanie Guenette has nothing to disclose. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol-Myers Squibb. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. The institution of Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen-Idec. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD-Serono. Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi-Genzyme. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Oh has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen-Idec. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi-Genzyme. The institution of Dr. Oh has received research support from Biogen-Idec. The institution of Dr. Oh has received research support from EMD-Serono. The institution of Dr. Oh has received research support from Biogen-Idec.