TY -的T1 -临床里程碑PSP和MSA作为姑息治疗干预触发器(p1 - 4.002) JF -神经学乔-神经学六世- 98 - 18补充SP - 687 AU -罗宾酸性非盟——真主安拉Iansavitchene AU首页 -玛丽·e·詹金斯AU -伊丽莎白手指盟Teneille Gofton Y1 - 2022/05/03 UR - //www.ez-admanager.com/content/98/18_Supplement/687.abstract N2 -目的:本范围回顾旨在总结文献有关生存在进行性核上的麻痹(PSP)和多系统萎缩(MSA)关注:1)临床里程碑,2)疾病轨迹,和3)的其他预测死亡率与neuropalliative护理在这个人口。背景:PSP和MSA进行性神经退行性疾病症状复杂轨迹和不可预测的疾病负担。neuropalliative保健的理想的起始时间是不确定的变量疾病轨迹紊乱。设计/方法:Medline和Embase数据库被用来确定出版物调查临床和生存在PSP和MSA的里程碑。医学图书馆员联合搜索策略。主要研究或系统评价的文献与临床的里程碑,疾病轨迹和其他预测死亡率在PSP和MSA是包括在内。相关研究被排除在外,如果他们只是症状管理,没有评估预后生存/,或发表在2010年之前。被评为质量和定性结果显示触发目标姑息治疗的疾病轨迹。结果:总共有2092条记录筛选,研究被认为无关紧要,2012和79的研究经历了全文回顾。24研究最终包括在内。“临床里程碑”点,提示进一步护理临床相关疾病。重要的里程碑包括频繁的瀑布,认知障碍,严重的构音障碍,严重的吞咽困难,轮椅依赖,尿导管插入术和制度化。 In PSP, early milestones included falls and cognitive impairment, while wheelchair dependence and urinary catheterization occurred later. In MSA, autonomic dysfunction and falls occurred early in the illness trajectory whereas institutionalization was a marker of advanced illness.Conclusions: Clinical milestones can be used to follow disease progression and help predict survival in PSP and MSA. We propose a milestone-driven framework in which milestones are used as triggers for targeted palliative care interventions including the early initiation of neuropalliative care.Disclosure: Dr. Bessemer has nothing to disclose. Ms. Iansavitchene has nothing to disclose. Dr. Jenkins has nothing to disclose. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vigil Neuro. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Vigil Neuro. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Denali Therapeutics. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NeuroImage Clinical. The institution of Dr. Finger has received research support from CIHR. The institution of Dr. Finger has received research support from Physician Servcices Incorporated. The institution of Dr. Finger has received research support from Weston Foundation. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving as a Annual Meeting Course Director with American Academy of Neurology. The institution of Dr. Gofton has received research support from Government of Canada. The institution of Dr. Gofton has received research support from Canadian Institutes of Health Research. The institution of Dr. Gofton has received research support from Academic Medical Organisation of Southwestern Ontario. Dr. Gofton has a non-compensated relationship as a Medical Advisory Board Member with NORSE Institute that is relevant to AAN interests or activities. ER -