TY - T1的癫痫手术后结果为MRI-Diagnosed焦皮质发育不良JF -神经学乔-神经病学SP - e236 LP - e248做- 10.1212 / WNL。首页0000000000013066六世- 98 - 3盟安娜·威拉德AU - Ana Antonic-Baker盟Zhibin陈盟-特伦斯约翰O ' brien AU -帕特里克关颖珊盟皮耶罗Perucca Y1 - 2022/01/18 UR - //www.ez-admanager.com/content/98/3/e236.abstract N2 -背景和目标首页焦点皮质发育不良(FCD)与贫穷有关手术后的癫痫发作的结果比其他疾病。FCD系列手术已组装的基础上组织学诊断,包括术前MRI异常患者和正常。然而,在临床工作流,患者选择手术是基于术前发现,包括核磁共振。我们进行了文献的系统回顾和荟萃分析来确定的速度和预测有利MRI-detected FCD癫痫手术后的结果。方法我们设计研究方案按照首选项报告系统评价和荟萃分析指南与普洛斯彼罗注册协议。我们搜查了MEDLINE和EMBASE,和网络科学研究的患者随访≥12个月resective手术后与MRI-detected FCD耐药性癫痫。随机分析是用来计算比例的患者获得良好的结果,我定义为恩格尔类,国际抗癫痫联盟类1到2,或控制发作状态。多元回归进行调查的异质性来源。我们的搜索结果确定3745年引用。其中,35研究(共有1353名患者)是包括在内。 Most studies (89%) followed up patients for ≥24 months after surgery. The overall postsurgical favorable outcome rate was 70% (95% confidence interval [CI] 64–75). There was high interstudy heterogeneity. Favorable outcome was associated with complete resection of the FCD lesion (risk ratio [RR] 2.42 [95% confidence interval (CI) 1.55–3.76], p < 0.001) and location of the FCD lesion in the temporal lobe (RR 1.38 [95% CI 1.07–1.79], p = 0.013) but not lesion extent, intracranial EEG use, or FCD histologic type. The number of FCD histologic types included in the same study accounted for 7.6% of the observed heterogeneity.Discussion Seventy percent of patients with drug-resistant epilepsy and MRI features of FCD attain a favorable seizure outcome after resective surgery. Our findings can be incorporated into routine preoperative counseling and reinforce the importance of completely resecting the MRI-detected FCD when safe and feasible.CI=confidence interval; ECoG=electrocorticography; FCD=focal cortical dysplasia; FLAIR=fluid-attenuated inversion recovery; ILAE=International League Against Epilepsy; NHLBI=National Heart, Lung and Blood Institute; PRISMA=Preferred Reporting Items for Systematic Reviews and Meta-Analyses; RR=risk ratio; SEEG=stereo-EEG ER -