@article {TekleS145作者= {Wondwossen Tekle和埃米尔·e·哈桑},标题={颅内动脉粥样硬化疾病},体积={97}={20补充2},页面= {S145——S157} = {2021}, doi = {10.1212 / WNL。出版商0000000000012805}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={审查的目的本文综述目前颅内动脉粥样硬化疾病的概念(ICAD)缺血性中风的常见病首页因;缺血性中风的病理生理机制;诊断评估;和治疗模式,包括最大药物治疗(MMT),经皮腔间血管成形术和支架植入(和平),和搭桥手术。最新发现的数据最近的研究表明,适当的病人的选择和时间过程和标准化的协议正在技术由经验丰富的运营商导致周期性不良事件的患者可以接受低MMT失败。摘要ICAD是缺血性中风的常见原因。复杂的病理和高复发和禁用缺血性中风尽管目前治疗使ICAD最具挑战性的治疗缺血性中风的病因。之前的随机试验表明MMT,包括使用抗血小板药物的组合,有针对性的控制高血压和血清低密度脂蛋白胆固醇、体重和适当的管理通过生活方式的修改,是优于正在减少利率ICAD症状的复发性缺血性中风。MMT表现好于预期,而在和平周期性并发症明显高于预期。与此同时,高复发性缺血性中风尽管MMT仍然是一个巨大的挑战。 New clinical evidence continues to emerge on a safer application of PTAS, which is currently offered to a subset of patients who present with recurrent ischemic strokes despite MMT.CASSISS=China Angioplasty and Stenting for Symptomatic Intracranial Severe Stenosis; CHANCE=Clopidogrel in High-Risk Patients With Acute Non-Disabling Cerebrovascular Events; CI=confidence interval; CLAIR=Clopidogrel Plus Aspirin Versus Aspirin Alone for Reducing Embolization in Patients With Acute Symptomatic Cerebral or Carotid Stenosis; CREST=Carotid Revascularization Endarterectomy Versus Stenting Trial; CTA=CT angiography; DAPT=dual antiplatelet therapy; DSA=digital subtraction angiography; EC-IC=extracranial-intracranial; EDAS=encephaloduroarteriosynangiosis; ESPRIT=European/Australian Stroke Prevention in Reversible Ischemia; FISS-tris=Fraxiparin in Stroke Study for the Treatment of Ischemic Stroke; HR=hazard ratio; HRvwMRI=high-resolution vessel wall MRI; ICAD=intracranial atherosclerotic disease; LDL-C=low-density lipoprotein cholesterol; MCA=middle cerebral artery; MMT=maximal medical therapy; MRA=magnetic resonance angiography; MT=mechanical thrombectomy; POINT=Platelet-Oriented Inhibition in New TIA and Minor Stroke; PTAS=percutaneous transluminal angioplasty and stenting; SAMMPRIS=Stenting Versus Aggressive Medical Management Therapy for Intracranial Arterial Stenosis; SOCRATES=Acute Stroke or Transient Ischemic Attack With Aspirin or Ticagrelor and Patient Outcomes; SPARCL=Stroke Prevention by Aggressive Reduction in Cholesterol Levels; TCD=transcranial Doppler; THALES=Acute Stroke or Transient Ischemic Attack Treated With Ticagrelor and Aspirin for Prevention of Stroke and Death; TOSS=Trial for Cilostazol in Symptomatic Intracranial Arterial Stenosis; VISSIT=Vitesse Intracranial Stent Study for Ischemic Stroke Therapy; VMR=vasomotor reactivity; WASID=Warfarin-Aspirin Symptomatic Intracranial Disease; WEAVE=Wingspan Stent System Post Market Surveillance; WOVEN=Wingspan One-Year Vascular Events and Neurologic Outcomes}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/97/20_Supplement_2/S145}, eprint = {//www.ez-admanager.com/content/97/20_Supplement_2/S145.full.pdf}, journal = {Neurology} }