TY - T1的临床、影像和病理特点,患者右和左Hemisphere-Predominant Logopenic进行性失语JF -神经学乔-神经病学SP - e523 LP - e534做- 10.1212 / WNL。首页0000000000012322六世- 97 - 5 AU -滨Buciuc盟-约瑟夫·r·达菲盟-玛丽·m·Machulda盟-乔纳森Graff-Radford AU -芽庄星期四Pham盟——彼得·r·马丁AU -马修·l·Senjem盟克利福德·r·杰克,Jr . AU - Nilufer Ertekin-Taner AU -丹尼斯·w·迪克森盟Val j·劳盟——詹妮弗·l·Whitwell盟——基思·安东尼·约瑟夫Y1 - 2021/08/03 UR - //www.ez-admanager.com/content/97/5/e523.abstract N2 -客观评估和比较人口、临床、神经影像学和病理特征的一群患者右hemisphere-predominant vs左hemisphere-predominant 首页logopenic进行性失语(LPA)。方法这是一个病例对照研究患者LPA的前瞻性是梅奥诊所和接受[18 f]氟脱氧葡萄糖(FDG) PET扫描。患者分为rLPA如果右颞叶代谢≥1 SD低于左颞叶的新陈代谢。rLPA患者相匹配3:1典型left-predominant LPA基于不对称程度和严重程度的颞叶的新陈代谢。患者临床相比,成像(MRI,摄影,β-amyloid,和tau-PET),和病理特征。结果103年前瞻性招募患者LPA、8(4女)被列为rLPA (7.8%);rLPA患者都是右撇子。rLPA有温和的失语症患者基于西部失语Battery-Aphasia商(p = 0.04),减少频繁的音韵学的错误(p = 0.015)。rLPA有较短的患者生存相比,典型的LPA:风险比为4.0 (1.2 - -12.9),p = 0.02。没有其他人口统计上的差异,用手习惯,遗传学,神经或神经心理测试。24相匹配典型患者LPA相比,患者rLPA显示更大的非惯用的额颞叶代谢减退半球摄影和杏仁核和海马萎缩的优势半球。 Autopsy evaluation revealed a similar distribution of pathologic findings in both groups, with Alzheimer disease pathologic changes being the most frequent pathology.Conclusions rLPA is associated with less severe aphasia but has shorter survival from reported symptom onset than typical LPA, possibly related to greater involvement of the nondominant hemisphere.Aβ=β-amyloid; AD=Alzheimer disease; AES=articulatory errors score; AQ=Aphasia Quotient; AVLT=Auditory Verbal Learning Test; BDAE=Boston Diagnostic Aphasia Examination; CAD=crossed aphasia in dextrals; CI=confidence interval; FBI=Frontal Behavioral Inventory; FDG=fluorodeoxyglucose; HR=hazard ratio; LPA=logopenic progressive aphasia; MCALT=Mayo Clinic Adult Lifespan Template; MoCA=Montreal Cognitive Assessment; MPRAGE=magnetization-prepared rapid-acquisition gradient-echo; NRG=Neurodegenerative Research Group; PiB=Pittsburgh compound B; PPA=primary progressive aphasia; PVC=partial volume correction; rLPA=right hemisphere–predominant logopenic progressive aphasia; SUVR=standard uptake value ratio; TDP-43=trans-active response DNA-binding protein 43 kDa; WAB=Western Aphasia Battery ER -