TY - T1的量化的脑铁沉积在帕金森病的不同阶段使用定量易感性映射(QSM) (2181) JF -神经学乔-神经学六世- 96 - 15补充SP - 2181 AU - Kailyn李盟- Josue Chasin盟Thanh阮Gillen盟盟-凯利-阿列克谢Dimov盟张爱玲AU -布莱恩Kopell AU -易首页王盟-亚历山大Shtilbans Y1 - 2021/04/13 UR - //www.ez-admanager.com/content/96/15_Supplement/2181.abstract N2 -目的:我们评估量化易感性映射(QSM)核磁共振技术来测量大脑的铁积累在帕金森病(PD)患者与健康对照组相比,不同阶段。背景:脑铁沉积在PD的发病机制有关。QSM出现大脑铁作为一种非侵入性技术来量化。然而,相关的大脑积累在黑质和其他铁原子核不完善的疾病的不同阶段。设计/方法:我们进行了一项横断面分析78例特发性帕金森病的MRI扫描(n = 16 Hoehn Yahr我(H& Y)阶段,n = 39 II期,n = 23 III&阶段;(四)和31名健康对照组。我们分析了黑质(SN)、红核(RN)、尾状核、壳核和苍白球QSM-processed图像获得磁化率值。结果:我们发现较高的铁积累SN的PD患者在所有阶段和控制(175.12±45.15磅的阶段我和180.89±44.77磅的II期和189.76±58.66磅的阶段III&第四和115.93±29.47磅的控制;术;0.001),在PD阶段没有统计上的显著差异。铁在RN在统计学上显著增加只有在II期和控件(十亿分之132.68±37.14和105.80±27.48磅;P = 0.0087)。尾状的铁含量,壳核和苍白球任何PD组没有差异和控制。结论:QSM可以测量铁基底神经节的PD患者。 Our data suggest brain iron accumulation occurs early in the disease course and only in the SN and RN of these patients. Neuromelanin, a natural chelator of iron in the SN, could account for the lack of increase of iron in advanced PD stages. This is a large cross-sectional study of brain iron deposition in PD according to H&Y staging. Prospective studies are warranted to further validate QSM as a method to measure brain iron, which could serve as a disease biomarker.Disclosure: Ms. Li has nothing to disclose. Josue Avecillas has nothing to disclose. Thanh Nguyen has nothing to disclose. Kelly Gillen has nothing to disclose. Alexey Dimov has nothing to disclose. Eileen Chang has nothing to disclose. Brian Kopell has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic. Brian Kopell has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbott Neuromodulation. Brian Kopell has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Enspire DBS. Prof. Wang has received intellectual property interests from a discovery or technology relating to health care. Dr. Shtilbans has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Acorda. Dr. Shtilbans has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Amneal. Dr. Shtilbans has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Kyowa Kirin. Dr. Shtilbans has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Neurocrine. Dr. Shtilbans has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for teva. Dr. Shtilbans has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for UCB. Dr. Shtilbans has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for US worldmeds. ER -