TY -的T1 MOG-Abs CSF只有:病理发现支持诊断作用(4181)JF -神经学乔-神经学六世- 96 - 15补充SP - 4181 AU -萨拉的法令AU -安娜Bolzan盟西尔维首页亚Bozzetti AU -伯内蒂布鲁诺盟Mauro Scarpelli称非盟-莎拉Ottaviani盟克劳迪奥·Ghimenton盟Daniela阿尔贝蒂AU -凯瑟琳Schanda盟Markus Reindl AU -罗曼Marignier AU -塞尔吉奥·法拉利盟莎拉Mariotto Y1 - 2021/04/13 UR - //www.ez-admanager.com/content/96/15_Supplement/4181.abstract N2 -目的:报告病人的临床和病理数据anti-myelin少突细胞糖蛋白抗体(MOG-Abs)脑脊液中发现。背景:血清MOG-Abs炎性脱髓鞘疾病的定义一个不同的实体,主要特点是亚急性发作视神经和/或脊髓受累。最近,我们提出了扩展的分析MOG-Abs CSF的高度提示血清反应阴性的情况下提高诊断的敏感性。然而,CSF MOG-Abs的确切价值需要进一步确认。设计/方法:NAResults:一个81岁的老人出现尿潴留其次是截瘫和L1感觉损失水平。脊髓MRI显示多个T2 hyperintense在脑干和脊髓病变,块状病变从中部簇状的圆锥T9,均匀和弥漫性脑膜增强脑干和脊髓表面增厚和增强腰骶神经根。CSF分析显示增加蛋白质含量(5.2 g / L),轻度淋巴细胞脑脊液细胞增多(29细胞/μL)和寡克隆乐队(模式3)。调查对传染病和血液学的条件产生了消极的结果。自身免疫性筛查,CSF只有MOG-Abs检测活细胞分析。尽管用大剂量静脉注射类固醇治疗,临床情况迅速恶化,上肢无力、多颅神经的参与,和严重的神经异常。病人死亡后15天症状发作。病态的宏观检验有水肿和坏死的迹象,主要包括脑干和脊髓颈。 On microscopic evaluation extensive activated macrophages infiltration was noted on the surface of brainstem and spinal cord. Perivascular and parenchymal lymphocytes (mixed CD20+ and CD3+ with some CD138+ plasma cells) were observed, involving also the leptomeninges.Conclusions: we herein report the first spinal cord pathological evaluation of a patient with isolated CSF MOG-Abs. Pathological findings, compatible with a subacute inflammatory process, further reinforce the importance of testing MOG-Abs in the CSF of highly suggestive cases.Disclosure: Sara Carta has nothing to disclose. Anna Bolzan has nothing to disclose. Silvia Bozzetti has nothing to disclose. Bruno Bonetti has nothing to disclose. Mauro Scarpelli has nothing to disclose. Sarah Ottaviani has nothing to disclose. Claudio Ghimenton has nothing to disclose. Daniela Alberti has nothing to disclose. Kathrin Schanda has nothing to disclose. The institution of Dr. Reindl has received research support from Euroimmun. The institution of Dr. Reindl has received research support from Roche. Dr. Marignier has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. Dr. Marignier has received personal compensation in the range of $0-$499 for serving as a Consultant for ALEXION. Dr. Marignier has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ROCHE. Sergio Ferrari has nothing to disclose. Dr. Mariotto has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. ER -