% 0期刊文章%该处Falgas马丁内斯%伊莎贝尔·e·艾伦%乔尔·克雷默%霍华德·罗森%一个布鲁斯·米勒%吉尔Rabinovici %一个托马斯Neylan Lea格林贝格% %克里斯汀·沃尔什% T神经精神症状在早期和晚期出现阿尔茨海默氏症(2452)% D J神经病学2021% % P V 96% 2452% N % X 15补充目的:确定微分EOAD NPS的轨迹和负载,在一群淀粉样蛋白阳性患者。首页背景:认知能力的衰退速度越快,非典型形式的优势早发性老年痴呆症(EOAD)表明,神经精神症状(NPS)可能比在迟发性的广告更常见于EOAD(负载)。然而,之前的研究基于non-biomarker诊断军团显示不一致的结果。设计/方法:115人会议NIA-AA标准广告,使用淀粉pet,在记忆和衰老招募中心,加州大学旧金山分校。参与者被分为EOAD(发病的年龄≤65年;n = 69)或负载(> 65年;n = 46)。caregiver-reported神经精神库存-问卷(NPI-Q)评价和随访(年度互访,从1到8年)。NPI-Q意味着比较基线和回归模型调整临床痴呆评定(CDR)纵向进行确定EOAD /负载的影响诊断NPI-Q分数。互动与遗忘/ non-amnestic变体也被评估。结果:没有EOAD和负载之间的区别性别(51 vs 59%),全球认知(MMSE 23.4±5和24.7±5)或功能性能(CDR总0.6±0.2 vs 0.6±0.3)。 Both groups were primarily amnestic AD (EOAD 71%, LOAD 80%). At baseline, both the NPI Total scores and certain subdomains scores (anxiety, irritability and nighttime behaviors) were higher in EOAD compared to LOAD (p<0.05). Longitudinally, EOAD predicted higher scores in NPI Total (p<0.01), nighttime behavior and motor disturbances (p<0.05). Non-amnestic EOAD showed higher anxiety than amnestic EOAD (p<0.05).Conclusions: NPS are more severe in EOAD than LOAD along the disease course, independent of the disease stage (CDR). Certain domains such as anxiety, irritability, nighttime behaviors and motor disturbances contribute to the differential pattern of NPS, suggesting there is a need to develop more tailored treatment strategies to address these clinical manifestations in EOAD.Disclosure: Neus Falgàs Martínez has nothing to disclose. Neus Falgàs Martínez has nothing to disclose. The institution of Dr. Kramer has received research support from tau consortium. Dr. Kramer has received publishing royalties from a publication relating to health care. Dr. Rosen has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Axon Neurosciences. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Eisai. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GE Healthcare. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Johnson & Joihnson. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Rabinovici has received research support from NIH. The institution of Dr. Rabinovici has received research support from American College of Radiology. The institution of Dr. Rabinovici has received research support from Alzheimer’s Association. The institution of Dr. Rabinovici has received research support from Rainwater Charitable Foundation. The institution of Dr. Rabinovici has received research support from Avid Radiopharmaceuticals. Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Topic Chair, Course Director and teacher with AAN. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH. Lea Grinberg has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Curasen Inc. The institution of Lea Grinberg has received research support from NIH. The institution of Lea Grinberg has received research support from Eli Lilly. The institution of Lea Grinberg has received research support from BrightFouus. The institution of Lea Grinberg has received research support from Rainwater Charity Foundation. The institution of Thomas Neylan has received research support from National Institutes of Aging. Dr. Walsh has nothing to disclose. %U